Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda, Hyeon Mo Cho, Myong Euy Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).

Original languageEnglish
Pages (from-to)7684-7687
Number of pages4
JournalRSC Advances
Volume3
Issue number21
DOIs
Publication statusPublished - 2013 Jun 7

Fingerprint

Carboxylic acids
Carboxylic Acids
2-amino-1,3,4-oxadiazole
thiosemicarbazide
isothiocyanic acid
1,3,4-oxadiazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

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title = "Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)",
abstract = "A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94{\%}).",
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Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS). / Guda, Dinneswara Reddy; Cho, Hyeon Mo; Lee, Myong Euy.

In: RSC Advances, Vol. 3, No. 21, 07.06.2013, p. 7684-7687.

Research output: Contribution to journalArticle

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AU - Guda, Dinneswara Reddy

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AU - Lee, Myong Euy

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AB - A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).

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