Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda, Hyeon Mo Cho, Myong Euy Lee

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8 Citations (Scopus)


A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71-87%).

Original languageEnglish
Pages (from-to)6813-6816
Number of pages4
JournalRSC Advances
Issue number19
Publication statusPublished - 2013 May 21


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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