Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease

Seok Jong Chung, Yeong Hun Park, Han Soo Yoo, Yang Hyun Lee, Byoung Seok Ye, Young H. Sohn, Jong Min Lee, Phil Hyu Lee

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9 Citations (Scopus)


This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's disease with mild cognitive impairment (PD-MCI). We recruited 217 patients with PD-MCI who underwent serial neuropsychological assessments 3–5 times (mean interval, 1.84 years). Thirty-six patients reverted to CogN (reverters) during follow-up, whereas the other 181 did not (nonreverters). We assessed the risk of cognitive worsening in PD-MCI reverters, nonreverters, and patients with PD-CogN (n = 88). In addition, we performed comparative analyses of comprehensive neuroimaging studies between the PD-MCI reverter (n = 17) and nonreverter (n = 34) subgroups. PD-MCI reverters had a lower risk of dementia conversion than nonreverters. In addition, PD-MCI reverters had similar risks of cognitive worsening with patients with PD-CogN. PD-MCI reverters exhibited greater cortical thickness in the right parahippocampal gyrus and less severely decreased functional connectivity in the default mode and executive control networks relative to nonreverters. Our results suggest that PD-MCI reverters have relatively preserved structural and functional integrity and a favorable cognitive prognosis compared with nonreverters.

Original languageEnglish
Pages (from-to)168-177
Number of pages10
JournalNeurobiology of Aging
Publication statusPublished - 2019 Jun

Bibliographical note

Funding Information:
This works was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (grant number: NRF- 2016R1A2A2A05920131 ), the Korea government (MSIP) (grant number: NRF- 2016R1A2B3016609 ), and the Ministry of Education (grant number: NRF- 2018R1D1A1B07048959 ).

Publisher Copyright:
© 2019 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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