Mimicking the functional niche of adipose-derived stem cells for regenerative medicine

Sireewan Kaewsuwan, Seung Yong Song, Ji Hye Kim, Jong Hyuk Sung

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Introduction: A stem cell (SC) niche is defined as the microenvironment in which the adult SC resides and includes surrounding cells, low oxygen content and growth factor gradients. Crosstalk between SCs and their niche provides signals that keep SCs quiescent, or modulates their activation. Areas covered: This review discusses the characterization of niche conditions in the adipose-derived stem cell (ASC) in vivo environment, and introduces key signalling pathways and autocrine/paracrine regulators of ASCs. Expert opinion: Control of in vivo niche factors (such as low oxygen content, generation of reactive oxygen species and activation of platelet-derived growth factor receptor signalling) should increase ASC yields synergistically and reduce production costs. Additionally, the preconditioning of ASCs with these niche factors prior to transplantation might enhance their regenerative potential. ASC niche is complex, and there are components of the niche that we may not yet understand. Therefore, future research needs to focus on identifying the key regulatory factors of the ASC niche in vivo, and developing a novel method to mimic these niche factors for in vitro manipulation.

Original languageEnglish
Pages (from-to)1575-1588
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume12
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Stem Cell Niche
Regenerative Medicine
Stem cells
Stem Cells
Autocrine Communication
Oxygen
Platelet-Derived Growth Factor Receptors
Adult Stem Cells
Expert Testimony
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
Transplantation
Chemical activation
Costs and Cost Analysis
Crosstalk
Costs

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Kaewsuwan, Sireewan ; Song, Seung Yong ; Kim, Ji Hye ; Sung, Jong Hyuk. / Mimicking the functional niche of adipose-derived stem cells for regenerative medicine. In: Expert Opinion on Biological Therapy. 2012 ; Vol. 12, No. 12. pp. 1575-1588.
@article{e06e11925003480db2cc991ad16a4fa6,
title = "Mimicking the functional niche of adipose-derived stem cells for regenerative medicine",
abstract = "Introduction: A stem cell (SC) niche is defined as the microenvironment in which the adult SC resides and includes surrounding cells, low oxygen content and growth factor gradients. Crosstalk between SCs and their niche provides signals that keep SCs quiescent, or modulates their activation. Areas covered: This review discusses the characterization of niche conditions in the adipose-derived stem cell (ASC) in vivo environment, and introduces key signalling pathways and autocrine/paracrine regulators of ASCs. Expert opinion: Control of in vivo niche factors (such as low oxygen content, generation of reactive oxygen species and activation of platelet-derived growth factor receptor signalling) should increase ASC yields synergistically and reduce production costs. Additionally, the preconditioning of ASCs with these niche factors prior to transplantation might enhance their regenerative potential. ASC niche is complex, and there are components of the niche that we may not yet understand. Therefore, future research needs to focus on identifying the key regulatory factors of the ASC niche in vivo, and developing a novel method to mimic these niche factors for in vitro manipulation.",
author = "Sireewan Kaewsuwan and Song, {Seung Yong} and Kim, {Ji Hye} and Sung, {Jong Hyuk}",
year = "2012",
month = "12",
day = "1",
doi = "10.1517/14712598.2012.721763",
language = "English",
volume = "12",
pages = "1575--1588",
journal = "Expert Opinion on Biological Therapy",
issn = "1471-2598",
publisher = "Informa Healthcare",
number = "12",

}

Mimicking the functional niche of adipose-derived stem cells for regenerative medicine. / Kaewsuwan, Sireewan; Song, Seung Yong; Kim, Ji Hye; Sung, Jong Hyuk.

In: Expert Opinion on Biological Therapy, Vol. 12, No. 12, 01.12.2012, p. 1575-1588.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mimicking the functional niche of adipose-derived stem cells for regenerative medicine

AU - Kaewsuwan, Sireewan

AU - Song, Seung Yong

AU - Kim, Ji Hye

AU - Sung, Jong Hyuk

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Introduction: A stem cell (SC) niche is defined as the microenvironment in which the adult SC resides and includes surrounding cells, low oxygen content and growth factor gradients. Crosstalk between SCs and their niche provides signals that keep SCs quiescent, or modulates their activation. Areas covered: This review discusses the characterization of niche conditions in the adipose-derived stem cell (ASC) in vivo environment, and introduces key signalling pathways and autocrine/paracrine regulators of ASCs. Expert opinion: Control of in vivo niche factors (such as low oxygen content, generation of reactive oxygen species and activation of platelet-derived growth factor receptor signalling) should increase ASC yields synergistically and reduce production costs. Additionally, the preconditioning of ASCs with these niche factors prior to transplantation might enhance their regenerative potential. ASC niche is complex, and there are components of the niche that we may not yet understand. Therefore, future research needs to focus on identifying the key regulatory factors of the ASC niche in vivo, and developing a novel method to mimic these niche factors for in vitro manipulation.

AB - Introduction: A stem cell (SC) niche is defined as the microenvironment in which the adult SC resides and includes surrounding cells, low oxygen content and growth factor gradients. Crosstalk between SCs and their niche provides signals that keep SCs quiescent, or modulates their activation. Areas covered: This review discusses the characterization of niche conditions in the adipose-derived stem cell (ASC) in vivo environment, and introduces key signalling pathways and autocrine/paracrine regulators of ASCs. Expert opinion: Control of in vivo niche factors (such as low oxygen content, generation of reactive oxygen species and activation of platelet-derived growth factor receptor signalling) should increase ASC yields synergistically and reduce production costs. Additionally, the preconditioning of ASCs with these niche factors prior to transplantation might enhance their regenerative potential. ASC niche is complex, and there are components of the niche that we may not yet understand. Therefore, future research needs to focus on identifying the key regulatory factors of the ASC niche in vivo, and developing a novel method to mimic these niche factors for in vitro manipulation.

UR - http://www.scopus.com/inward/record.url?scp=84869419889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869419889&partnerID=8YFLogxK

U2 - 10.1517/14712598.2012.721763

DO - 10.1517/14712598.2012.721763

M3 - Review article

C2 - 22953993

AN - SCOPUS:84869419889

VL - 12

SP - 1575

EP - 1588

JO - Expert Opinion on Biological Therapy

JF - Expert Opinion on Biological Therapy

SN - 1471-2598

IS - 12

ER -