Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

Wook Bin Lee, Ji Seon Kang, Won Young Choi, Quanri Zhang, Chul Han Kim, Un Yung Choi, Jeongsil Kim-Ha, Young-Joon Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In response to persistent mycobacteria infection, the host induces a granuloma, which often fails to eradicate bacteria and results in tissue damage. Diverse host receptors are required to control the formation and resolution of granuloma, but little is known concerning their regulatory interactions. Here we show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production. In addition to its stimulatory role on TLR-mediated transcription, Mincle enhanced the translation of key genes required for nitric oxide synthesis through p38 and eIF5A hypusination, leading to granuloma resolution. Thus, Mincle has dual functions in the promotion and subsequent resolution of inflammation during anti-mycobacterial defence using both transcriptional and translational controls.

Original languageEnglish
Article number11322
JournalNature communications
Volume7
DOIs
Publication statusPublished - 2016 Apr 18

Fingerprint

nitric oxide
Granuloma
Nitric Oxide
Cord Factors
Inflammation
Macrophages
Transcription
Bacteria
Mycobacterium Infections
macrophages
Genes
Switches
promotion
infectious diseases
Tissue
Cytokines
genes
bacteria
switches
damage

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lee, Wook Bin ; Kang, Ji Seon ; Choi, Won Young ; Zhang, Quanri ; Kim, Chul Han ; Choi, Un Yung ; Kim-Ha, Jeongsil ; Kim, Young-Joon. / Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. In: Nature communications. 2016 ; Vol. 7.
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Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. / Lee, Wook Bin; Kang, Ji Seon; Choi, Won Young; Zhang, Quanri; Kim, Chul Han; Choi, Un Yung; Kim-Ha, Jeongsil; Kim, Young-Joon.

In: Nature communications, Vol. 7, 11322, 18.04.2016.

Research output: Contribution to journalArticle

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AU - Lee, Wook Bin

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