Mitochondria-targeted vitamin E protects skin from UVB-irradiation

Won Serk Kim, Ikyon Kim, Wang Kyun Kim, Ju Yeon Choi, Doo Yeong Kim, Sung Guk Moon, Hyung Keun Min, Min Kyu Song, Jong Hyuk Sung

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalBiomolecules and Therapeutics
Volume24
Issue number3
DOIs
Publication statusPublished - 2016 May

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Mitochondria-targeted vitamin E protects skin from UVB-irradiation'. Together they form a unique fingerprint.

  • Cite this

    Kim, W. S., Kim, I., Kim, W. K., Choi, J. Y., Kim, D. Y., Moon, S. G., Min, H. K., Song, M. K., & Sung, J. H. (2016). Mitochondria-targeted vitamin E protects skin from UVB-irradiation. Biomolecules and Therapeutics, 24(3), 305-311. https://doi.org/10.4062/biomolther.2015.131