Mitochondria-targeted vitamin E protects skin from UVB-irradiation

Won Serk Kim, Ikyon Kim, Wang Kyun Kim, Ju Yeon Choi, Doo Yeong Kim, Sung Guk Moon, Hyung Keun Min, Min Kyu Song, Jong Hyuk Sung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalBiomolecules and Therapeutics
Volume24
Issue number3
DOIs
Publication statusPublished - 2016 May 1

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Mitochondria
Vitamin E
Skin
Irradiation
Fibroblasts
Wound Healing
Reactive Oxygen Species
Animals
Cosmetics
Keratinocytes
Dosimetry
Cell Survival
Raw materials
Lasers
Collagen
Down-Regulation
Animal Models
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Kim, Won Serk ; Kim, Ikyon ; Kim, Wang Kyun ; Choi, Ju Yeon ; Kim, Doo Yeong ; Moon, Sung Guk ; Min, Hyung Keun ; Song, Min Kyu ; Sung, Jong Hyuk. / Mitochondria-targeted vitamin E protects skin from UVB-irradiation. In: Biomolecules and Therapeutics. 2016 ; Vol. 24, No. 3. pp. 305-311.
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Kim, WS, Kim, I, Kim, WK, Choi, JY, Kim, DY, Moon, SG, Min, HK, Song, MK & Sung, JH 2016, 'Mitochondria-targeted vitamin E protects skin from UVB-irradiation', Biomolecules and Therapeutics, vol. 24, no. 3, pp. 305-311. https://doi.org/10.4062/biomolther.2015.131

Mitochondria-targeted vitamin E protects skin from UVB-irradiation. / Kim, Won Serk; Kim, Ikyon; Kim, Wang Kyun; Choi, Ju Yeon; Kim, Doo Yeong; Moon, Sung Guk; Min, Hyung Keun; Song, Min Kyu; Sung, Jong Hyuk.

In: Biomolecules and Therapeutics, Vol. 24, No. 3, 01.05.2016, p. 305-311.

Research output: Contribution to journalArticle

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