Mitochondrial gene transfer ribonucleic acid (tRNA)(Leu(UUR)) 3243 and tRNA(Lys) 8344 mutations and diabetes mellitus in Korea

Hyun Chul Lee, Young Duk Song, Hai Ri Li, Jum Ok Park, Hyung Chan Suh, Eunjik Lee, Seungkil Lim, Kyungrae Kim, Kapbum Huh

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The high prevalence of diabetic patients with a mutation in the mitocbondrial gene (the 3243 and 8344 bp mutations) has been identified in Japan. To determine the prevalence of diabetic patients with those mutations in Korea, we randomly screened selected 503 clinical diabetic patients regardless of their diabetes types. We found only 1 patient with the mitochondrial DNA mutation at position 3243 (percent mutation, 32%), and the mitochondrial DNA mutation at position 8344 was not found in any of the patients. The affected subject was a 22-yr-old man with a history of myoclonic epilepsy and mild sensorineural hearing loss, a 1-yr duration of diabetes mellitus, and a low level C peptide response to oral glucose. Because of the low frequency of these mutations in the Korean diabetic population, we concluded that these particular mutations of mitochondrial DNA may not be a common contributor to diabetes mellitus in Korea.

Original languageEnglish
Pages (from-to)372-374
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume82
Issue number2
DOIs
Publication statusPublished - 1997 Jan 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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