Mitochondrial quality control in the heart: New drug targets for cardiovascular disease

Chang Myung Oh, Dongryeol Ryu, Sungsoo Cho, Yangsoo Jang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.

Original languageEnglish
Pages (from-to)395-405
Number of pages11
JournalKorean Circulation Journal
Volume50
Issue number5
DOIs
Publication statusPublished - 2020 Jan 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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