Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

Tae Im Kim, Jhang Ho Pak, Ju Byung Chae, Eung Kweon Kim, Hungwon Tchah

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). Methods: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. Results: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. Conclusion: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalCornea
Volume25
Issue number2
DOIs
Publication statusPublished - 2006 Feb

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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