Mizoribine versus mycophenolate mofetil in combination therapy with tacrolimus for de novo kidney transplantation: Evaluation of efficacy and safety

M. K. Ju, K. H. Huh, K. T. Park, S. J. Kim, B. H. Cho, C. D. Kim, B. J. So, C. M. Kang, S. Lee, D. J. Joo, Y. S. Kim

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Abstract

The present study compared the efficacy and safety of mizoribine (MZR) with mycophenolate mofetil (MMF) in kidney transplantation. This multicenter, randomized clinical trial. Employed doses of study drug tailored to the immunosuppressive need. The primary efficacy outcome was the incidence of biopsy-proven acute rejection episodes (BPAR). The safety of the study drug was assessed using the incidences of adverse events, drug discontinuations, and abnormal laboratory results. The 7 (6.4%) BPARs above grade II were observed in the MZR group noninferior to the 2 (1.8%) in the MMF group (95% confidence interval, -0.007-0.097 > noninferiority limit [-0.2]). BPAR was significantly decreased in the MZR group after the dose change (17/41 [41.4%] vs 8/69 [11.6%]; P <.0001) and the incidence of BPAR was similar between the MZR and MMF groups after the dose change (P =.592). The uric acid level was significantly elevated in the MZR group (P =.002). In conclusion, the efficacy and safety of MZR were similar and statistically noninferior to MMF in combination therapy with tacrolimus.

Original languageEnglish
Pages (from-to)1481-1486
Number of pages6
JournalTransplantation Proceedings
Volume45
Issue number4
DOIs
Publication statusPublished - 2013 May 1

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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