Abstract
We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all analyzed cells, and the results of fluorescence in situ hybridization (FISH) and multi-color FISH analysis confirmed this unique MLL rearrangement as a sole abnormality. To our knowledge, t(6;11)(q13∼q15;q23) is the most rare type of MLL rearrangement involving the long arm of chromosome 6. Only two cases with t(6;11)(q13;q23) and three cases with t(6;11)(q15;q23) have been reported, but detailed clinical or laboratory data were not available. From this report, it is apparent that in a cytogenetic laboratory, the accurate detection of a rare type of MLL rearrangement is very important in the differential diagnosis, prompt treatment, and prediction of prognosis of leukemias.
| Original language | English |
|---|---|
| Pages (from-to) | 50-53 |
| Number of pages | 4 |
| Journal | Cancer genetics and cytogenetics |
| Volume | 187 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
- Cancer Research
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MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia : conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. / Park, Tae Sung; Lee, Seung Tae; Song, Jaewoo; Lee, Kyung A.; Lee, Sang Guk; Kim, Juwon; Suh, Borum; Kim, Sue Jung; Lee, Jong Han; Park, Rojin; Choi, Jong Rak.
In: Cancer genetics and cytogenetics, Vol. 187, No. 1, 01.11.2008, p. 50-53.Research output: Contribution to journal › Article
TY - JOUR
T1 - MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia
T2 - conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities
AU - Park, Tae Sung
AU - Lee, Seung Tae
AU - Song, Jaewoo
AU - Lee, Kyung A.
AU - Lee, Sang Guk
AU - Kim, Juwon
AU - Suh, Borum
AU - Kim, Sue Jung
AU - Lee, Jong Han
AU - Park, Rojin
AU - Choi, Jong Rak
PY - 2008/11/1
Y1 - 2008/11/1
N2 - We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all analyzed cells, and the results of fluorescence in situ hybridization (FISH) and multi-color FISH analysis confirmed this unique MLL rearrangement as a sole abnormality. To our knowledge, t(6;11)(q13∼q15;q23) is the most rare type of MLL rearrangement involving the long arm of chromosome 6. Only two cases with t(6;11)(q13;q23) and three cases with t(6;11)(q15;q23) have been reported, but detailed clinical or laboratory data were not available. From this report, it is apparent that in a cytogenetic laboratory, the accurate detection of a rare type of MLL rearrangement is very important in the differential diagnosis, prompt treatment, and prediction of prognosis of leukemias.
AB - We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all analyzed cells, and the results of fluorescence in situ hybridization (FISH) and multi-color FISH analysis confirmed this unique MLL rearrangement as a sole abnormality. To our knowledge, t(6;11)(q13∼q15;q23) is the most rare type of MLL rearrangement involving the long arm of chromosome 6. Only two cases with t(6;11)(q13;q23) and three cases with t(6;11)(q15;q23) have been reported, but detailed clinical or laboratory data were not available. From this report, it is apparent that in a cytogenetic laboratory, the accurate detection of a rare type of MLL rearrangement is very important in the differential diagnosis, prompt treatment, and prediction of prognosis of leukemias.
UR - http://www.scopus.com/inward/record.url?scp=55049131167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55049131167&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2008.07.012
DO - 10.1016/j.cancergencyto.2008.07.012
M3 - Article
C2 - 18992643
AN - SCOPUS:55049131167
VL - 187
SP - 50
EP - 53
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -