MnPS3 shows anticancer behaviour towards lung cancer cells

Naziah Mohamad Latiff; Nur Farhanah Rosli; Carmen C. Mayorga-Martinez; Katerina Szokolava; Zdenek Sofer; Adrian C. Fisher; Martin Pumera

doi:10.1016/j.flatc.2019.100134

MnPS₃ shows anticancer behaviour towards lung cancer cells

Naziah Mohamad Latiff, Nur Farhanah Rosli, Carmen C. Mayorga-Martinez, Katerina Szokolava, Zdenek Sofer, Adrian C. Fisher, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Here, we report the anticancer behaviour of MnPS₃ towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS₃ treatment. We found that MnPS₃ triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS₃ in biomedical applications.

Original language	English
Article number	100134
Journal	FlatChem
Volume	18
DOIs	https://doi.org/10.1016/j.flatc.2019.100134
Publication status	Published - 2019 Nov

Bibliographical note

Funding Information:
A. C. F., N. M. L. and N. F. R. were funded by Singapore’s National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S ) and Neuron Foundation for Science . Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X ).

Funding Information:
A. C. F. N. M. L. and N. F. R. were funded by Singapore's National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S) and Neuron Foundation for Science. Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X).

Publisher Copyright:
© 2019 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Surfaces, Coatings and Films
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.flatc.2019.100134

Cite this

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title = "MnPS3 shows anticancer behaviour towards lung cancer cells",

abstract = "Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.",

author = "{Mohamad Latiff}, Naziah and Rosli, {Nur Farhanah} and Mayorga-Martinez, {Carmen C.} and Katerina Szokolava and Zdenek Sofer and Fisher, {Adrian C.} and Martin Pumera",

note = "Funding Information: A. C. F., N. M. L. and N. F. R. were funded by Singapore{\textquoteright}s National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S ) and Neuron Foundation for Science . Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X ). Funding Information: A. C. F. N. M. L. and N. F. R. were funded by Singapore's National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S) and Neuron Foundation for Science. Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X). Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

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AU - Sofer, Zdenek

AU - Fisher, Adrian C.

AU - Pumera, Martin

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