MnPS3 shows anticancer behaviour towards lung cancer cells

Naziah Mohamad Latiff, Nur Farhanah Rosli, Carmen C. Mayorga-Martinez, Katerina Szokolava, Zdenek Sofer, Adrian C. Fisher, Martin Pumera

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.

Original languageEnglish
Article number100134
JournalFlatChem
Volume18
DOIs
Publication statusPublished - 2019 Nov

Bibliographical note

Funding Information:
A. C. F., N. M. L. and N. F. R. were funded by Singapore’s National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S ) and Neuron Foundation for Science . Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X ).

Funding Information:
A. C. F. N. M. L. and N. F. R. were funded by Singapore's National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S) and Neuron Foundation for Science. Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X).

Publisher Copyright:
© 2019 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Surfaces, Coatings and Films
  • Materials Chemistry

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