Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.
Bibliographical noteFunding Information:
A. C. F., N. M. L. and N. F. R. were funded by Singapore’s National Research Foundation (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z.S. acknowledges the Czech Science Foundation (GACR No. 17-11456S ) and Neuron Foundation for Science . Real-time apoptosis/necrosis assay was kindly provided by Promega, Singapore. M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19-26896X ).
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Materials Chemistry