Modeling of the permeate flux during microfiltration of BSA-adsorbed microspheres in a stirred cell

Sung Wook Choi, Jeong Yeol Yoon, Seungjoo Haam, Joon Ki Jung, Jung Hyun Kim, Woo Sik Kim

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26 Citations (Scopus)


A study on the variation of the permeate flux was performed in a stirred cell charged with microspheres, to investigate the effects of the stirrer speeds (300, 400, and 600 rpm) and the BSA concentration (0.1, 0.2, 0.4, and 0.8 g/L) under constant pressure. The permeate flux increased over time before the saturation point, but it began to decrease after that point. An increase of the BSA concentration and the stirrer speed resulted in the rapid increase of the permeate flux. This is contrary to the observation of the conventional filtration experiments using a stirred cell. A resistance-in-series model was employed for the modeling of the permeate flux. The cake resistance (R(c), induced by the concentration polarization of microspheres) and the fouling resistance (R(f), induced by the adsorption of BSA inside the membrane pore) must be considered simultaneously for the modeling. These modeling results were in good agreement with the experimental data. These can be applied to the special system considering both R(c) and R(f) as well as the general filtration systems using a stirred cell. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)270-278
Number of pages9
JournalJournal of Colloid and Interface Science
Issue number2
Publication statusPublished - 2000 Aug 15

Bibliographical note

Funding Information:
The authors acknowledge the financial support of Bioproducts Research Center, Yonsei University, Grant 94U4-1005-00-01-6 and the Korea Institute of S&T Evaluation and Planning (KISTEP) made in the program year of 1999.

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry


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