Modification of TiO2 nanotube surfaces by electro-spray deposition of amoxicillin combined with PLGA for bactericidal effects at surgical implantation sites

Jung Hwan Lee, Seung Kyun Moon, Kwang Mahn Kim, Kyoung Nam Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective. To fabricate the antibiotic-releasing coatings on TiO 2 nanotube surfaces for wide applications of implant and bone plate in medical and dental surgery, the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures was found. Materials and methods. FE-SEM, ESD and FT-IR were used for confirming deposition of amoxicillin/PLGA on the TiO2 surface. Also, the elution of amoxicillin/PLGA in a TiO 2 nanotube surface was measured by a UV-VIS spectrophotometer. The bactericidal effect of amoxicillin on the TiO2 nanotube surface was evaluated by using Staphylococcus aureus (S. aureus). The cytotoxicity and cell proliferation were observed by WST assay using MC3T3-E1 osteoblast cells. Results. The results indicated that the TiO2 nanotube surface controlled by electro-spray deposition time with amoxicillin/PLGA solution could provide a high bactericidal effect against S. aureus by the bactericidal effect of amoxicillin, as well as good osteoblast cell proliferation at the TiO 2 nanotube surface without toxicity. Conclusions. This study used electro-spray deposition (ESD) methodology to obtain amoxicillin deposition in nanotube structures of TiO2 and found the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalActa odontologica Scandinavica
Volume71
Issue number1
DOIs
Publication statusPublished - 2013 Feb

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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