Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Chung Kyu Ryu, Hyeh Jean Jeong, Sang Kook Lee, Hye Young Kang, Kyung Min Ko, Yang Jung Sun, Eun Ha Song, Yeon Hoe Hur, Chong Ock Lee

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Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalArchives of pharmacal research
Issue number6
Publication statusPublished - 2000 Jan 1


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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