Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Chung Kyu Ryu, Hyeh Jean Jeong, Sang Kook Lee, Hye-Young Kang, Kyung Min Ko, Yang Jung Sun, Eun Ha Song, Yeon Hoe Hur, Chong Ock Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalArchives of pharmacal research
Volume23
Issue number6
DOIs
Publication statusPublished - 2000 Jan 1

Fingerprint

NAD
Oxidoreductases
Cells
Modulation
Cytotoxicity
Cell Line
Cytotoxins
Human Activities
Lung Neoplasms
Neoplasms
Modulators
benzoquinone

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Ryu, Chung Kyu ; Jeong, Hyeh Jean ; Lee, Sang Kook ; Kang, Hye-Young ; Ko, Kyung Min ; Sun, Yang Jung ; Song, Eun Ha ; Hur, Yeon Hoe ; Lee, Chong Ock. / Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential. In: Archives of pharmacal research. 2000 ; Vol. 23, No. 6. pp. 554-558.
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Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential. / Ryu, Chung Kyu; Jeong, Hyeh Jean; Lee, Sang Kook; Kang, Hye-Young; Ko, Kyung Min; Sun, Yang Jung; Song, Eun Ha; Hur, Yeon Hoe; Lee, Chong Ock.

In: Archives of pharmacal research, Vol. 23, No. 6, 01.01.2000, p. 554-558.

Research output: Contribution to journalArticle

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AU - Ryu, Chung Kyu

AU - Jeong, Hyeh Jean

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AU - Kang, Hye-Young

AU - Ko, Kyung Min

AU - Sun, Yang Jung

AU - Song, Eun Ha

AU - Hur, Yeon Hoe

AU - Lee, Chong Ock

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