Mohs micrographic surgery for dermatofibrosarcoma protuberans

comparison of frozen and paraffin techniques

S. H. Lee, Y. Oh, K. A. Nam, B. Oh, MiRyung Roh, K. Y. Chung

Research output: Contribution to journalArticle

Abstract

Background: Due to the propensity for local recurrence, Mohs micrographic surgery (MMS) has been suggested for the treatment of dermatofibrosarcoma protuberans (DFSP) and it has shown improved clinical outcomes. Recently, some authors suggested that MMS using paraffin-embedded sections (paraffin MMS) is superior in DFSP treatment compared with the conventional frozen MMS method. However, there have been no studies comparing frozen and paraffin MMS for the treatment of DFSP. Objectives: To compare the outcomes between DFSP patients who underwent frozen MMS and paraffin MMS. Methods: Seventy-one DFSP patients treated with frozen MMS (n = 30) or paraffin MMS (n = 41) from 2003 to 2017 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival between frozen and paraffin MMS were assessed. Results: During the mean follow-up duration of 25.4 months, four patients (frozen MMS, n = 1; and paraffin MMS, n = 3) showed recurrence after MMS. Although the local recurrence rate of the frozen MMS group (3.3%) was lower than that of the paraffin MMS group (7.3%), the difference was not statistically significant. In addition, recurrence-free survival was not significantly different between the two groups (P = 0.168). Conclusions: Frozen MMS, which has the advantages of shorter surgery time and immediate closure, is as effective as paraffin MMS in the treatment of DFSP.

Original languageEnglish
Pages (from-to)2171-2177
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Volume32
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Dermatofibrosarcoma
Mohs Surgery
Paraffin
Recurrence

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

@article{e9c9abd1b65646a9a8e721c74c8034a2,
title = "Mohs micrographic surgery for dermatofibrosarcoma protuberans: comparison of frozen and paraffin techniques",
abstract = "Background: Due to the propensity for local recurrence, Mohs micrographic surgery (MMS) has been suggested for the treatment of dermatofibrosarcoma protuberans (DFSP) and it has shown improved clinical outcomes. Recently, some authors suggested that MMS using paraffin-embedded sections (paraffin MMS) is superior in DFSP treatment compared with the conventional frozen MMS method. However, there have been no studies comparing frozen and paraffin MMS for the treatment of DFSP. Objectives: To compare the outcomes between DFSP patients who underwent frozen MMS and paraffin MMS. Methods: Seventy-one DFSP patients treated with frozen MMS (n = 30) or paraffin MMS (n = 41) from 2003 to 2017 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival between frozen and paraffin MMS were assessed. Results: During the mean follow-up duration of 25.4 months, four patients (frozen MMS, n = 1; and paraffin MMS, n = 3) showed recurrence after MMS. Although the local recurrence rate of the frozen MMS group (3.3{\%}) was lower than that of the paraffin MMS group (7.3{\%}), the difference was not statistically significant. In addition, recurrence-free survival was not significantly different between the two groups (P = 0.168). Conclusions: Frozen MMS, which has the advantages of shorter surgery time and immediate closure, is as effective as paraffin MMS in the treatment of DFSP.",
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Mohs micrographic surgery for dermatofibrosarcoma protuberans : comparison of frozen and paraffin techniques. / Lee, S. H.; Oh, Y.; Nam, K. A.; Oh, B.; Roh, MiRyung; Chung, K. Y.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 32, No. 12, 01.12.2018, p. 2171-2177.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mohs micrographic surgery for dermatofibrosarcoma protuberans

T2 - comparison of frozen and paraffin techniques

AU - Lee, S. H.

AU - Oh, Y.

AU - Nam, K. A.

AU - Oh, B.

AU - Roh, MiRyung

AU - Chung, K. Y.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Due to the propensity for local recurrence, Mohs micrographic surgery (MMS) has been suggested for the treatment of dermatofibrosarcoma protuberans (DFSP) and it has shown improved clinical outcomes. Recently, some authors suggested that MMS using paraffin-embedded sections (paraffin MMS) is superior in DFSP treatment compared with the conventional frozen MMS method. However, there have been no studies comparing frozen and paraffin MMS for the treatment of DFSP. Objectives: To compare the outcomes between DFSP patients who underwent frozen MMS and paraffin MMS. Methods: Seventy-one DFSP patients treated with frozen MMS (n = 30) or paraffin MMS (n = 41) from 2003 to 2017 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival between frozen and paraffin MMS were assessed. Results: During the mean follow-up duration of 25.4 months, four patients (frozen MMS, n = 1; and paraffin MMS, n = 3) showed recurrence after MMS. Although the local recurrence rate of the frozen MMS group (3.3%) was lower than that of the paraffin MMS group (7.3%), the difference was not statistically significant. In addition, recurrence-free survival was not significantly different between the two groups (P = 0.168). Conclusions: Frozen MMS, which has the advantages of shorter surgery time and immediate closure, is as effective as paraffin MMS in the treatment of DFSP.

AB - Background: Due to the propensity for local recurrence, Mohs micrographic surgery (MMS) has been suggested for the treatment of dermatofibrosarcoma protuberans (DFSP) and it has shown improved clinical outcomes. Recently, some authors suggested that MMS using paraffin-embedded sections (paraffin MMS) is superior in DFSP treatment compared with the conventional frozen MMS method. However, there have been no studies comparing frozen and paraffin MMS for the treatment of DFSP. Objectives: To compare the outcomes between DFSP patients who underwent frozen MMS and paraffin MMS. Methods: Seventy-one DFSP patients treated with frozen MMS (n = 30) or paraffin MMS (n = 41) from 2003 to 2017 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival between frozen and paraffin MMS were assessed. Results: During the mean follow-up duration of 25.4 months, four patients (frozen MMS, n = 1; and paraffin MMS, n = 3) showed recurrence after MMS. Although the local recurrence rate of the frozen MMS group (3.3%) was lower than that of the paraffin MMS group (7.3%), the difference was not statistically significant. In addition, recurrence-free survival was not significantly different between the two groups (P = 0.168). Conclusions: Frozen MMS, which has the advantages of shorter surgery time and immediate closure, is as effective as paraffin MMS in the treatment of DFSP.

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JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

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