Molecular and cellular toxicological profiling of DNA bis-intercalator, quinoxaline compounds: echinomycin as the versatile lead

Yoon Sun Park, Woon Seob Shin, Cheol Su Kim, Chan Mug Ahn, Xu Feng Qi, Soo-Ki Kim

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Of quinoxaline compounds, echinomycin is classically known as an antitumor agent which binds to DNA via a mechanism of bis-intercalation. In addition to intercalation, quinoxaline compounds such as echinomycin, echinomycin derivatives or analogues might control anomalous cellular proliferation in eukaryotes via specifically triggering cellular signaling pathways in mitochondria, as well as under hypoxia. Further, since echinomycin was proven to be a specific inhibitor of HIF-1α, these novel mechanisms could be clinically applied in the development of therapeutics against cancer, infection, obesity, fibrosis, and autoimmune disease. Herein, this review focuses on the current toxicological profiles of echinomycin as well its potential applications in medicine.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalMolecular and Cellular Toxicology
Volume14
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Echinomycin
Intercalating Agents
Quinoxalines
DNA Fingerprinting
Toxicology
DNA
Cell signaling
Intercalation compounds
Mitochondria
Bioelectric potentials
Intercalation
Eukaryota
Antineoplastic Agents
Autoimmune Diseases
Medicine
Fibrosis
Obesity
Cell Proliferation
Lead
Derivatives

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Park, Yoon Sun ; Shin, Woon Seob ; Kim, Cheol Su ; Ahn, Chan Mug ; Qi, Xu Feng ; Kim, Soo-Ki. / Molecular and cellular toxicological profiling of DNA bis-intercalator, quinoxaline compounds : echinomycin as the versatile lead. In: Molecular and Cellular Toxicology. 2018 ; Vol. 14, No. 1. pp. 9-18.
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abstract = "Of quinoxaline compounds, echinomycin is classically known as an antitumor agent which binds to DNA via a mechanism of bis-intercalation. In addition to intercalation, quinoxaline compounds such as echinomycin, echinomycin derivatives or analogues might control anomalous cellular proliferation in eukaryotes via specifically triggering cellular signaling pathways in mitochondria, as well as under hypoxia. Further, since echinomycin was proven to be a specific inhibitor of HIF-1α, these novel mechanisms could be clinically applied in the development of therapeutics against cancer, infection, obesity, fibrosis, and autoimmune disease. Herein, this review focuses on the current toxicological profiles of echinomycin as well its potential applications in medicine.",
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Molecular and cellular toxicological profiling of DNA bis-intercalator, quinoxaline compounds : echinomycin as the versatile lead. / Park, Yoon Sun; Shin, Woon Seob; Kim, Cheol Su; Ahn, Chan Mug; Qi, Xu Feng; Kim, Soo-Ki.

In: Molecular and Cellular Toxicology, Vol. 14, No. 1, 01.01.2018, p. 9-18.

Research output: Contribution to journalReview article

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AB - Of quinoxaline compounds, echinomycin is classically known as an antitumor agent which binds to DNA via a mechanism of bis-intercalation. In addition to intercalation, quinoxaline compounds such as echinomycin, echinomycin derivatives or analogues might control anomalous cellular proliferation in eukaryotes via specifically triggering cellular signaling pathways in mitochondria, as well as under hypoxia. Further, since echinomycin was proven to be a specific inhibitor of HIF-1α, these novel mechanisms could be clinically applied in the development of therapeutics against cancer, infection, obesity, fibrosis, and autoimmune disease. Herein, this review focuses on the current toxicological profiles of echinomycin as well its potential applications in medicine.

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