Molecular and engineering approaches to regenerate and repair teeth in mammals

Wing Fu Lai, Jong Min Lee, Han Sung Jung

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Continuous replacement of teeth throughout the lifespan of an individual is possibly basal for most of the vertebrates including fish and reptiles; however, mammals generally have a limited capacity of tooth renewal. The ability to induce cellular differentiation in adults to replace lost or damaged cells in mammals, or to tissue-engineer organs in vitro, has hence become one of the major goals of regenerative medicine. In this article, we will revisit some of the important signals and tissue interactions that regulate mammalian tooth development, and will offer a synopsis of the latest progress in tooth regeneration and repair via molecular and engineering approaches. It is hoped that this article will not only offer an overview of recent technologies in tooth regeneration and repair but will also stimulate more interdisciplinary research in this field to turn the pursuit of tooth regeneration and repair into practical reality.

Original languageEnglish
Pages (from-to)1691-1701
Number of pages11
JournalCellular and Molecular Life Sciences
Volume71
Issue number9
DOIs
Publication statusPublished - 2014 May

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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