Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia

Juwon Kim, Sang Guk Lee, Jaewoo Song, Soo Jeong Kim, SunYoung Rha, Kyunga Lee, Tae Sung Park, Jong Rak Choi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cryptic deletions are occasionally reported in hematologic malignancies. The SET-NUP214 fusion gene has been rarely reported in acute myeloid leukemia, acute undifferentiated leukemia, and recurrently in T-cell acute lymphoblastic leukemia. The fusion product is generated by a submicroscopic deletion in the vicinity of 9q34. Herein we present a novel case of acute undifferentiated leukemia with SET-NUP214 rearrangement due to the cryptic deletion of the 9q34 region producing two different types of fusion transcripts by alternative splicing and molecular characterization of the fusion transcripts by fluorescence in situ hybridization, reverse transcriptase-polymerase chain reaction, and array comparative genomic hybridization analyses.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume201
Issue number2
DOIs
Publication statusPublished - 2010 Sep 1

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Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Comparative Genomic Hybridization
Gene Fusion
Alternative Splicing
Hematologic Neoplasms
Reverse Transcriptase Polymerase Chain Reaction
Fluorescence In Situ Hybridization
Acute Myeloid Leukemia

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Kim, Juwon ; Lee, Sang Guk ; Song, Jaewoo ; Kim, Soo Jeong ; Rha, SunYoung ; Lee, Kyunga ; Park, Tae Sung ; Choi, Jong Rak. / Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia. In: Cancer Genetics and Cytogenetics. 2010 ; Vol. 201, No. 2. pp. 73-80.
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Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia. / Kim, Juwon; Lee, Sang Guk; Song, Jaewoo; Kim, Soo Jeong; Rha, SunYoung; Lee, Kyunga; Park, Tae Sung; Choi, Jong Rak.

In: Cancer Genetics and Cytogenetics, Vol. 201, No. 2, 01.09.2010, p. 73-80.

Research output: Contribution to journalArticle

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