Molecular classification of metaplastic carcinoma using surrogate immunohistochemical staining

Hye Min Kim, Do Hee Kim, Woo Hee Jung, Ja Seung Koo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. Methods: Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, androgen receptor and GGT was performed and classified into basal-like, molecular apocrine, claudin-low, immune-related, mixed and null types. Results: Among the 34 cases of metaplastic carcinoma, 13 were of the basal-like type (35.2%), 9 of the mixed type (26.5%), 8 of the null type (23.5%), 3 of the claudin-low type (8.8%), and 1 was of the molecular apocrine type (2.9%). Depending on the cell type, there were differences between molecular subtypes, with the matrix-producing type occupying the largest proportion in the basal-like, null and mixed types. The spindle cell type represented the largest proportion in the claudin-low and molecular apocrine types, and the squamous cell type characterized the largest proportion in the basal-like type. Conclusion: Following molecular subtyping of metaplastic carcinomas using surrogate IHC markers, the largest number of cases was of the basal-like type, followed by the mixed, null, claudin-low and molecular apocrine types. There were differences between molecular subtypes according to the cell type.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalPathobiology
Volume81
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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Claudin-3
Staining and Labeling
Carcinoma
Cadherins
Claudin-4
Keratin-6
Tissue Array Analysis
Keratin-5
Androgen Receptors
Epidermal Growth Factor Receptor
Biomarkers
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Kim, Hye Min ; Kim, Do Hee ; Jung, Woo Hee ; Koo, Ja Seung. / Molecular classification of metaplastic carcinoma using surrogate immunohistochemical staining. In: Pathobiology. 2014 ; Vol. 81, No. 2. pp. 69-77.
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Molecular classification of metaplastic carcinoma using surrogate immunohistochemical staining. / Kim, Hye Min; Kim, Do Hee; Jung, Woo Hee; Koo, Ja Seung.

In: Pathobiology, Vol. 81, No. 2, 01.02.2014, p. 69-77.

Research output: Contribution to journalArticle

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N2 - Objective: The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. Methods: Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, androgen receptor and GGT was performed and classified into basal-like, molecular apocrine, claudin-low, immune-related, mixed and null types. Results: Among the 34 cases of metaplastic carcinoma, 13 were of the basal-like type (35.2%), 9 of the mixed type (26.5%), 8 of the null type (23.5%), 3 of the claudin-low type (8.8%), and 1 was of the molecular apocrine type (2.9%). Depending on the cell type, there were differences between molecular subtypes, with the matrix-producing type occupying the largest proportion in the basal-like, null and mixed types. The spindle cell type represented the largest proportion in the claudin-low and molecular apocrine types, and the squamous cell type characterized the largest proportion in the basal-like type. Conclusion: Following molecular subtyping of metaplastic carcinomas using surrogate IHC markers, the largest number of cases was of the basal-like type, followed by the mixed, null, claudin-low and molecular apocrine types. There were differences between molecular subtypes according to the cell type.

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