Molecular classification of triple-negative breast cancer

Sung Gwe Ahn, Seung Jun Kim, Cheungyeul Kim, Joon Jeong

Research output: Contribution to journalReview articlepeer-review

54 Citations (Scopus)

Abstract

Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these studies identically suggested that TNBC consists of four major subtypes: basal-like, mesenchymal, luminal androgen receptor, and immune-en-riched. By reviewing these methods of classifications of TNBC, we highlight the unmet need to develop a molecular classifier suited for TNBC.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalJournal of Breast Cancer
Volume19
Issue number3
DOIs
Publication statusPublished - 2016 Sep

Bibliographical note

Funding Information:
This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C3396).

Publisher Copyright:
© 2016 Korean Breast Cancer Society. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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