Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

Soo Mee Bang, Ji Weon Seo, Kyung Un Park, Seok Jin Kim, Kihyun Kim, Sun Hee Kim, Sung Ran Cho, Hugh C. Kim, Jaewoo Song, Jin Seok Kim, Kyung Hee Kim, Jae Hoon Lee, Je Jung Lee, Myung Geun Shin, Cheolwon Suh, Hyun Sook Chi, Do yeun Oh, Jong Ho Won, Hyo Jung Kim, Sung Soo YoonDong Soon Lee

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10 Citations (Scopus)

Abstract

To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalCancer genetics and cytogenetics
Volume197
Issue number2
DOIs
Publication statusPublished - 2010 Mar

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Bang, S. M., Seo, J. W., Park, K. U., Kim, S. J., Kim, K., Kim, S. H., Cho, S. R., Kim, H. C., Song, J., Kim, J. S., Kim, K. H., Lee, J. H., Lee, J. J., Shin, M. G., Suh, C., Chi, H. S., Oh, D. Y., Won, J. H., Kim, H. J., ... Lee, D. S. (2010). Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. Cancer genetics and cytogenetics, 197(2), 117-121. https://doi.org/10.1016/j.cancergencyto.2009.11.008