Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

Soo Mee Bang, Ji Weon Seo, Kyung Un Park, Seok Jin Kim, Kihyun Kim, Sun Hee Kim, Sung Ran Cho, Hugh C. Kim, Jaewoo Song, Jinseok Kim, Kyung Hee Kim, Jae Hoon Lee, Je Jung Lee, Myung Geun Shin, Cheolwon Suh, Hyun Sook Chi, Do yeun Oh, Jong Ho Won, Hyo Jung Kim, Sung Soo Yoon & 1 others Dong Soon Lee

Research output: Contribution to journalArticle

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Abstract

To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalCancer genetics and cytogenetics
Volume197
Issue number2
DOIs
Publication statusPublished - 2010 Mar 1

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Waldenstrom Macroglobulinemia
Cytogenetic Analysis
Multiple Myeloma
Fluorescence In Situ Hybridization
Trisomy
Abnormal Karyotype
Karyotyping
Interphase
Cytogenetics
Immunoglobulins
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Bang, S. M., Seo, J. W., Park, K. U., Kim, S. J., Kim, K., Kim, S. H., ... Lee, D. S. (2010). Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. Cancer genetics and cytogenetics, 197(2), 117-121. https://doi.org/10.1016/j.cancergencyto.2009.11.008
Bang, Soo Mee ; Seo, Ji Weon ; Park, Kyung Un ; Kim, Seok Jin ; Kim, Kihyun ; Kim, Sun Hee ; Cho, Sung Ran ; Kim, Hugh C. ; Song, Jaewoo ; Kim, Jinseok ; Kim, Kyung Hee ; Lee, Jae Hoon ; Lee, Je Jung ; Shin, Myung Geun ; Suh, Cheolwon ; Chi, Hyun Sook ; Oh, Do yeun ; Won, Jong Ho ; Kim, Hyo Jung ; Yoon, Sung Soo ; Lee, Dong Soon. / Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. In: Cancer genetics and cytogenetics. 2010 ; Vol. 197, No. 2. pp. 117-121.
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title = "Molecular cytogenetic analysis of Korean patients with Waldenstr{\"o}m macroglobulinemia",
abstract = "To compare the molecular cytogenetic characteristics between Waldenstr{\"o}m macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18{\%}) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10{\%}). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45{\%}), followed by IgH translocation (42{\%}) and gain of 1q (38{\%}). In conclusion, Korean WM patients had a low rate of 6q deletion (10{\%}) and no trisomy 4.",
author = "Bang, {Soo Mee} and Seo, {Ji Weon} and Park, {Kyung Un} and Kim, {Seok Jin} and Kihyun Kim and Kim, {Sun Hee} and Cho, {Sung Ran} and Kim, {Hugh C.} and Jaewoo Song and Jinseok Kim and Kim, {Kyung Hee} and Lee, {Jae Hoon} and Lee, {Je Jung} and Shin, {Myung Geun} and Cheolwon Suh and Chi, {Hyun Sook} and Oh, {Do yeun} and Won, {Jong Ho} and Kim, {Hyo Jung} and Yoon, {Sung Soo} and Lee, {Dong Soon}",
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Bang, SM, Seo, JW, Park, KU, Kim, SJ, Kim, K, Kim, SH, Cho, SR, Kim, HC, Song, J, Kim, J, Kim, KH, Lee, JH, Lee, JJ, Shin, MG, Suh, C, Chi, HS, Oh, DY, Won, JH, Kim, HJ, Yoon, SS & Lee, DS 2010, 'Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia', Cancer genetics and cytogenetics, vol. 197, no. 2, pp. 117-121. https://doi.org/10.1016/j.cancergencyto.2009.11.008

Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. / Bang, Soo Mee; Seo, Ji Weon; Park, Kyung Un; Kim, Seok Jin; Kim, Kihyun; Kim, Sun Hee; Cho, Sung Ran; Kim, Hugh C.; Song, Jaewoo; Kim, Jinseok; Kim, Kyung Hee; Lee, Jae Hoon; Lee, Je Jung; Shin, Myung Geun; Suh, Cheolwon; Chi, Hyun Sook; Oh, Do yeun; Won, Jong Ho; Kim, Hyo Jung; Yoon, Sung Soo; Lee, Dong Soon.

In: Cancer genetics and cytogenetics, Vol. 197, No. 2, 01.03.2010, p. 117-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

AU - Bang, Soo Mee

AU - Seo, Ji Weon

AU - Park, Kyung Un

AU - Kim, Seok Jin

AU - Kim, Kihyun

AU - Kim, Sun Hee

AU - Cho, Sung Ran

AU - Kim, Hugh C.

AU - Song, Jaewoo

AU - Kim, Jinseok

AU - Kim, Kyung Hee

AU - Lee, Jae Hoon

AU - Lee, Je Jung

AU - Shin, Myung Geun

AU - Suh, Cheolwon

AU - Chi, Hyun Sook

AU - Oh, Do yeun

AU - Won, Jong Ho

AU - Kim, Hyo Jung

AU - Yoon, Sung Soo

AU - Lee, Dong Soon

PY - 2010/3/1

Y1 - 2010/3/1

N2 - To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

AB - To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

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U2 - 10.1016/j.cancergencyto.2009.11.008

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