Molecular determinants mediating gating of transient receptor potential canonical (TRPC) channels by stromal interaction molecule 1 (STIM1)

Kyu Pil Lee, Seok Choi, Jeong Hee Hong, Malini Ahuja, Sarabeth Graham, Rong Ma, Insuk So, Dong Min Shin, Shmuel Muallem, Joseph P. Yuan

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background: STIM1 gates TRPC channels, but the interacting domains are unknown. Results: The TRPC N and C terminus coiled coil domains interact to restrict access of STIM1. Their dissociation by cell stimulation promotes STIM1 interaction. Conclusion: The STIM1 Orai1-activating region (SOAR) domain interacts with the TRPC C terminus CCD to open the channels. Significance: The findings reveal how STIM1 opens the TRPC channels to control receptor-stimulated Ca2+ influx.

Original languageEnglish
Pages (from-to)6372-6382
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
Publication statusPublished - 2014 Mar 7

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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