Molecular mechanism of pancreatic and salivary gland fluid and HCO 3 - secretion

Min Goo Lee, Ehud Ohana, Hyun Woo Park, Dongki Yang, Shmuel Muallem

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

Fluid and HCO 3 - secretion is a vital function of all epithelia and is required for the survival of the tissue. Aberrant fluid and HCO 3 - secretion is associated with many epithelial diseases, such as cystic fibrosis, pancreatitis, Sjögren's syndrome, and other epithelial inflammatory and autoimmune diseases. Significant progress has been made over the last 20 years in our understanding of epithelial fluid and HCO 3 - secretion, in particular by secretory glands. Fluid and HCO 3 - secretion by secretory glands is a two-step process. Acinar cells secrete isotonic fluid in which the major salt is NaCl. Subsequently, the duct modifies the volume and electrolyte composition of the fluid to absorb the Cl - and secrete HCO 3 -. The relative volume secreted by acinar and duct cells and modification of electrolyte composition of the secreted fluids varies among secretory glands to meet their physiological functions. In the pancreas, acinar cells secrete a small amount of NaCl-rich fluid, while the duct absorbs the Cl - and secretes HCO 3 - and the bulk of the fluid in the pancreatic juice. Fluid secretion appears to be driven by active HCO 3 - secretion. In the salivary glands, acinar cells secrete the bulk of the fluid in the saliva that is driven by active Cl - secretion and contains high concentrations of Na + and Cl -. The salivary glands duct absorbs both the Na + and Cl - and secretes K + and HCO 3 -. In this review, we focus on the molecular mechanism of fluid and HCO 3 - secretion by the pancreas and salivary glands, to highlight the similarities of the fundamental mechanisms of acinar and duct cell functions, and to point out the differences to meet gland-specific secretions.

Original languageEnglish
Pages (from-to)39-74
Number of pages36
JournalPhysiological Reviews
Volume92
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Acinar Cells
Salivary Glands
Electrolytes
Pancreas
Salivary Ducts
Fluids and Secretions
Pancreatic Juice
Tissue Survival
Saliva
Cystic Fibrosis
Pancreatitis
Autoimmune Diseases
Epithelium
Salts

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Lee, Min Goo ; Ohana, Ehud ; Park, Hyun Woo ; Yang, Dongki ; Muallem, Shmuel. / Molecular mechanism of pancreatic and salivary gland fluid and HCO 3 - secretion. In: Physiological Reviews. 2012 ; Vol. 92, No. 1. pp. 39-74.
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Molecular mechanism of pancreatic and salivary gland fluid and HCO 3 - secretion. / Lee, Min Goo; Ohana, Ehud; Park, Hyun Woo; Yang, Dongki; Muallem, Shmuel.

In: Physiological Reviews, Vol. 92, No. 1, 01.01.2012, p. 39-74.

Research output: Contribution to journalReview article

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