The International Committee for Classification of Corneal Dystrophies (IC3D) provides updated data to ophthalmologists by incorporating traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Recent advances in the genetics of corneal dystrophies facilitate more precise classifications and elucidate each classification's molecular mechanisms. Unfortunately, the molecular mechanisms and underlying pathogenic mechanisms have remained obscure, with the exception of Schnyder corneal dystrophy (CD), granular CD type 2 (GCD2), and Fuch's endothelial CD. Here, we review the pathogenesis of Schnyder CD and GCD2.
|Title of host publication||Molecular Biology of Eye Disease, 2015|
|Editors||John M. Nickerson, J. Fielding Hejtmancik|
|Number of pages||17|
|Publication status||Published - 2015|
|Name||Progress in Molecular Biology and Translational Science|
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2011‐0028699).
© 2015 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology