Molecular Pathogenesis of Corneal Dystrophies: Schnyder Dystrophy and Granular Corneal Dystrophy type 2

Eung Kweon Kim, Hun Lee, Seung Il Choi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The International Committee for Classification of Corneal Dystrophies (IC3D) provides updated data to ophthalmologists by incorporating traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Recent advances in the genetics of corneal dystrophies facilitate more precise classifications and elucidate each classification's molecular mechanisms. Unfortunately, the molecular mechanisms and underlying pathogenic mechanisms have remained obscure, with the exception of Schnyder corneal dystrophy (CD), granular CD type 2 (GCD2), and Fuch's endothelial CD. Here, we review the pathogenesis of Schnyder CD and GCD2.

Original languageEnglish
Title of host publicationMolecular Biology of Eye Disease, 2015
EditorsJohn M. Nickerson, J. Fielding Hejtmancik
PublisherElsevier B.V.
Pages99-115
Number of pages17
ISBN (Print)9780128010594
DOIs
Publication statusPublished - 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume134
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2011‐0028699).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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