Molecular targets of exercise mimetics and their natural activators

Young Jin Jang, Sanguine Byun

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Physical exercise can be effective in preventing or ameliorating various diseases, including diabetes, cardiovascular diseases,neurodegenerative diseases, and cancer. However, not everyonemay be able to participate in exercise due to illnesses, age-relatedfrailty, or difficulty in long-term behavior change. Analternative option is to utilize pharmacological interventions thatmimic the positive effects of exercise training. Recent studieshave identified signaling pathways associated with the benefitsof physical activity and discovered exercise mimetics that canpartially simulate the systemic impact of exercise. This reviewdescribes the molecular targets for exercise mimetics and theireffect on skeletal muscle and other tissues.

Original languageEnglish
Pages (from-to)581-591
Number of pages11
JournalBMB reports
Issue number12
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This research was supported by a research grant from Seoul Women’s University (2020-0452) and the Yonsei University Research Fund of 2020-22-0073.

Publisher Copyright:
© 2021. by the The Korean Society for Biochemistry and Molecular Biology

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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