Monoclonal and polyclonal antibodies specific for foot and mouth disease virus type A and type O VP1

Jin Gu Cho, Yeong Joon Jo, Jong Hyuk Sung, Jang Kwan Hong, Ji Hyeon Hwang, Jong Hyeon Park, Kwang Nyeong Lee, Sang Gyu Park

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4 Citations (Scopus)

Abstract

The foot and mouth disease virus (FMDV) is an RNA virus composed of single stranded positive sense RNA. FMDV has been known to infect cloven-hoofed animals, including pigs, cattle, and sheep. FMDV is rapidly spreading outward to neighboring regions, often leading to a high mortality rate. Thus, early diagnosis of FMDV is critical to suppress propagation of FMDV and minimize economic losses. In this study, we report the generation and characterization of polyclonal and six monoclonal antibodies against VP1 through immunoblotting and immunofluorescence microscopy analyses. These VP1 antibodies will be useful as tools to detect serotypes A and O of FMDVs for diagnostic usage.

Original languageEnglish
Pages (from-to)358-363
Number of pages6
JournalHybridoma
Volume31
Issue number5
DOIs
Publication statusPublished - 2012 Oct 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Cho, J. G., Jo, Y. J., Sung, J. H., Hong, J. K., Hwang, J. H., Park, J. H., Lee, K. N., & Park, S. G. (2012). Monoclonal and polyclonal antibodies specific for foot and mouth disease virus type A and type O VP1. Hybridoma, 31(5), 358-363. https://doi.org/10.1089/hyb.2012.0034