Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection

Kwang Soo Shin, Insu Jeon, Byung Seok Kim, Il Kyu Kim, Young Jun Park, Choong Hyun Koh, Boyeong Song, Jeong Mi Lee, Jiyoung Lim, Eun Ah Bae, Hyungseok Seo, Young Ho Ban, Sang Jun Ha, Chang Yuil Kang

Research output: Contribution to journalArticle

Abstract

Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.

Original languageEnglish
Article number1887
JournalFrontiers in Immunology
Volume10
Issue numberAUG
DOIs
Publication statusPublished - 2019 Jan 1

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Dendritic Cells
Monocytes
T-Lymphocytes
Infection
T Cell Transcription Factor 1
Lymphocytic choriomeningitis virus
Antigen-Presenting Cells
Interferons
Interleukin-2
Cell Differentiation
Immunity
Up-Regulation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Shin, K. S., Jeon, I., Kim, B. S., Kim, I. K., Park, Y. J., Koh, C. H., ... Kang, C. Y. (2019). Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection. Frontiers in Immunology, 10(AUG), [1887]. https://doi.org/10.3389/fimmu.2019.01887
Shin, Kwang Soo ; Jeon, Insu ; Kim, Byung Seok ; Kim, Il Kyu ; Park, Young Jun ; Koh, Choong Hyun ; Song, Boyeong ; Lee, Jeong Mi ; Lim, Jiyoung ; Bae, Eun Ah ; Seo, Hyungseok ; Ban, Young Ho ; Ha, Sang Jun ; Kang, Chang Yuil. / Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection. In: Frontiers in Immunology. 2019 ; Vol. 10, No. AUG.
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Shin, KS, Jeon, I, Kim, BS, Kim, IK, Park, YJ, Koh, CH, Song, B, Lee, JM, Lim, J, Bae, EA, Seo, H, Ban, YH, Ha, SJ & Kang, CY 2019, 'Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection', Frontiers in Immunology, vol. 10, no. AUG, 1887. https://doi.org/10.3389/fimmu.2019.01887

Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection. / Shin, Kwang Soo; Jeon, Insu; Kim, Byung Seok; Kim, Il Kyu; Park, Young Jun; Koh, Choong Hyun; Song, Boyeong; Lee, Jeong Mi; Lim, Jiyoung; Bae, Eun Ah; Seo, Hyungseok; Ban, Young Ho; Ha, Sang Jun; Kang, Chang Yuil.

In: Frontiers in Immunology, Vol. 10, No. AUG, 1887, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Shin, Kwang Soo

AU - Jeon, Insu

AU - Kim, Byung Seok

AU - Kim, Il Kyu

AU - Park, Young Jun

AU - Koh, Choong Hyun

AU - Song, Boyeong

AU - Lee, Jeong Mi

AU - Lim, Jiyoung

AU - Bae, Eun Ah

AU - Seo, Hyungseok

AU - Ban, Young Ho

AU - Ha, Sang Jun

AU - Kang, Chang Yuil

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.

AB - Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.

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