Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?

Joohyun Park, Ji Young Chang, Jong Youl Kim, Jong Eun Lee

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the invasion of blood cells and other macromolecules is broken down within minutes, thereby triggering the inflammation cascade, including the infiltration of peripheral blood leukocytes. In this series of processes, blood-derived monocytes have a significant effect on the outcome of ischemic stroke through neuroinflammatory responses. As neuroinflammation is a necessary and pivotal component of the reparative process after ischemic stroke, understanding the role of infiltrating monocytes in the modulation of inflammatory responses may offer a great opportunity to explore new therapies for ischemic stroke. In this review, we discuss and highlight the function and involvement of monocytes in the brain after ischemic injury, as well as their impact on tissue damage and repair.

Original languageEnglish
Article number578003
JournalFrontiers in Neurology
Publication statusPublished - 2020 Oct 22

Bibliographical note

Funding Information:
The authors thank the staff of Medical Illustration & Design, which is part of the Medical Research Support Services of the Yonsei University College of Medicine, for all the artistic support related to this work. The authors would also like to thank Editage ( for English language editing. Funding. JL secured funding for this research, which was supported by grants from the National Research Foundation of Korea and the Ministry of Science, ICT and Future Planning (NRF-2016M3C7A1905098).

Funding Information:
JL secured funding was supported by Research Foundation of Science, ICT 2016M3C7A1905098).

Publisher Copyright:
© Copyright © 2020 Park, Chang, Kim and Lee.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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