Monotherapy in patients with type 2 diabetes mellitus

On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalDiabetes and Metabolism Journal
Volume41
Issue number5
DOIs
Publication statusPublished - 2017 Oct 1

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Type 2 Diabetes Mellitus
Metformin
Therapeutics
Drug-Related Side Effects and Adverse Reactions
Hypoglycemia
Hypoglycemic Agents
Weight Gain
Blood Glucose
Life Style
Early Diagnosis
Diabetes Mellitus
Quality of Life
Safety
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association (2017). Monotherapy in patients with type 2 diabetes mellitus. Diabetes and Metabolism Journal, 41(5), 349-356. https://doi.org/10.4093/dmj.2017.41.5.349
On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association. / Monotherapy in patients with type 2 diabetes mellitus. In: Diabetes and Metabolism Journal. 2017 ; Vol. 41, No. 5. pp. 349-356.
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abstract = "In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.",
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On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association 2017, 'Monotherapy in patients with type 2 diabetes mellitus', Diabetes and Metabolism Journal, vol. 41, no. 5, pp. 349-356. https://doi.org/10.4093/dmj.2017.41.5.349

Monotherapy in patients with type 2 diabetes mellitus. / On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association.

In: Diabetes and Metabolism Journal, Vol. 41, No. 5, 01.10.2017, p. 349-356.

Research output: Contribution to journalReview article

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AU - On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association

AU - Rhee, Sang Youl

AU - Kim, Hyun Jin

AU - Ko, Seung Hyun

AU - Hur, Kyu Yeon

AU - Kim, Nan Hee

AU - Moon, Min Kyong

AU - Park, Seok O.

AU - Lee, Byung Wan

AU - Choi, Kyung Mook

AU - Kim, Jin Hwa

AU - Kim, Tae Nyun

AU - Lee, Yong Ho

AU - Kim, Jin Hwa

AU - Hong, Eun Gyoung

AU - Kim, Jaetaek

AU - Lee, Won Young

AU - Song, Bokrye

AU - Kim, Ji Young

AU - Yang, Dong Hee

AU - Taeyoung Yang, Yang

AU - Hyeongjin Kim, Kim

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N2 - In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.

AB - In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.

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On behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association. Monotherapy in patients with type 2 diabetes mellitus. Diabetes and Metabolism Journal. 2017 Oct 1;41(5):349-356. https://doi.org/10.4093/dmj.2017.41.5.349