Background. The therapeutic efficacy of percutaneous transluminal coronary angioplasty is limited by the incidence of restenosis. Intracoronary irradiation has shown to be effective in restenosis control by inhibiting the neointimal proliferation. Methods and Results. Monte Carlo simulation has been performed to calculate the dose to the vessel wall for intracoronary irradiation with a rhenium 188 solution-filled balloon for restenosis inhibition. With a 3-mm-diameter and 30-mm-long balloon, the radiation dose at 1 mm from the balloon surface was 5.3% lower when the balloon structure was included in geometric modeling of the angioplasty catheter, as compared with that obtained by ignoring the structure. The additional dose reduction due to Hexabrix 320 contrast medium added in 30% of volume ratio was 4.7 %. With regard to axial dose distribution, the dose was uniform over the balloon length except near the balloon end, at which the dose was reduced by 35% at a 1-mm-deep layer in the vessel wall. With the Re-188 solution mixed with 30% of Hexabrix 320 in volume ratio, the Re-188 activity to be injected for delivery of 15 Gy to the 1-mm-deep layer by 1-minute irradiation was 27.3 GBq/mL. Conclusions. Dose estimates produced in this study should be helpful in determining the Re-188 activity to be injected or the irradiation time for a varying situation in terms of length and diameter of the irradiated arterial segment and depth of the target layer.
Bibliographical noteFunding Information:
From the Laboratory of Cyclotron Applicationa and Department of Nuclear Medicine,c Korea Cancer Center Hospital, and the Depart-ment of Nuclear Medicineb and Division of Cardiology, Department of Medicine,d Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. This work was supported by the Nuclear R&D Program of the MOST (Korea Ministry of Science and Technology) and the Interdiscipli-nary Research Program of the KOSEF (Korea Science and Engi-neering Foundation). Received for publication July 9, 2001; final revision accepted Oct 23, 2001. Reprint requests: Eun-Hee Kim, Laboratory of Cyclotron Application, Korea Cancer Center Hospital, 215-4 Gongneung-dong Nowon-gu, Seoul 139-706, Korea; firstname.lastname@example.org. Copyright © 2002 by the American Society of Nuclear Cardiology. 1071-3581/2002/$35.00 + 0 43/1/121232 doi:10.1067/mnc.2002.121232
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine