Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

Joong B. Ahn, Kwang Y. Shim, Hei C. Jeung, SunYoung Rha, Nae C. Yoo, Namkyu Kim, Jae K. Roh, Jin S. Min, Byung S. Kim, Hyuncheol Chung

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Abstract

We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes' B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m 2 of 5-FU and 20 mg/m 2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes' C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalCancer Letters
Volume167
Issue number2
DOIs
Publication statusPublished - 2001 Jun 26

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Leucovorin
Adjuvant Chemotherapy
Fluorouracil
Colonic Neoplasms
Survival
Disease-Free Survival
Body Surface Area
Appointments and Schedules
Multivariate Analysis
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ahn, Joong B. ; Shim, Kwang Y. ; Jeung, Hei C. ; Rha, SunYoung ; Yoo, Nae C. ; Kim, Namkyu ; Roh, Jae K. ; Min, Jin S. ; Kim, Byung S. ; Chung, Hyuncheol. / Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer. In: Cancer Letters. 2001 ; Vol. 167, No. 2. pp. 215-224.
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abstract = "We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes' B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m 2 of 5-FU and 20 mg/m 2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes' C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.",
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Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer. / Ahn, Joong B.; Shim, Kwang Y.; Jeung, Hei C.; Rha, SunYoung; Yoo, Nae C.; Kim, Namkyu; Roh, Jae K.; Min, Jin S.; Kim, Byung S.; Chung, Hyuncheol.

In: Cancer Letters, Vol. 167, No. 2, 26.06.2001, p. 215-224.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

AU - Ahn, Joong B.

AU - Shim, Kwang Y.

AU - Jeung, Hei C.

AU - Rha, SunYoung

AU - Yoo, Nae C.

AU - Kim, Namkyu

AU - Roh, Jae K.

AU - Min, Jin S.

AU - Kim, Byung S.

AU - Chung, Hyuncheol

PY - 2001/6/26

Y1 - 2001/6/26

N2 - We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes' B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m 2 of 5-FU and 20 mg/m 2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes' C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.

AB - We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes' B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m 2 of 5-FU and 20 mg/m 2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes' C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.

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