Morphogenesis of Cell-Shaped Assemblies via Heterotypic Assembly of Cyclic Triblock Peptides

Hyoseok Kim; Sooho Ko; Keunwan Park; Yong beom Lim

doi:10.1002/macp.202200103

Morphogenesis of Cell-Shaped Assemblies via Heterotypic Assembly of Cyclic Triblock Peptides

Hyoseok Kim, Sooho Ko, Keunwan Park, Yong beom Lim

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Despite the high prevalence and functional significance of nonregular assemblies in biology, little attention has been given to realize them in artificial systems. Here, the discovery of general principles underlying the formation of nonregular objects is described by chemical self-assembly. The cell-shaped assemblies (CSAs) are characterized by a main body comprising a nonregular vesicle and dendritically shaped spiky projections. The major mechanisms of CSA morphogenesis are: first, polycrystalline structures consisting of grains and grain boundaries induce the formation of nonregular objects by promoting nonuniform supramolecular crystal growth. Second, the fibrous nanostructures in 2D networks and in 1D bundles firmly support the main body and the spiky projections, respectively. This study also shows that there exist certain connections among entirely disparate entities, that is, organic supramolecular assemblies, inorganic materials, and cells regarding their fundamental principles of building block organizations. The principle behind the CSA formation can be applied to control the dynamic and mechanical properties of self-assembled materials.

Original language	English
Article number	2200103
Journal	Macromolecular Chemistry and Physics
Volume	223
Issue number	16
DOIs	https://doi.org/10.1002/macp.202200103
Publication status	Published - 2022 Aug

Bibliographical note

Funding Information:
The authors thank the Korea Basic Science Institute (KBSI) for Cryo-SEM experiments and the Pohang Accelerator Laboratory (PAL) for X-ray diffraction (XRD) experiments. This work was supported by grants from the National Research Foundation (NRF) of Korea (2020R1A2C2007578 and 2022M3E5F1016877).

Funding Information:
The authors thank the Korea Basic Science Institute (KBSI) for Cryo‐SEM experiments and the Pohang Accelerator Laboratory (PAL) for X‐ray diffraction (XRD) experiments. This work was supported by grants from the National Research Foundation (NRF) of Korea (2020R1A2C2007578 and 2022M3E5F1016877).

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Condensed Matter Physics
Physical and Theoretical Chemistry
Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/macp.202200103

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abstract = "Despite the high prevalence and functional significance of nonregular assemblies in biology, little attention has been given to realize them in artificial systems. Here, the discovery of general principles underlying the formation of nonregular objects is described by chemical self-assembly. The cell-shaped assemblies (CSAs) are characterized by a main body comprising a nonregular vesicle and dendritically shaped spiky projections. The major mechanisms of CSA morphogenesis are: first, polycrystalline structures consisting of grains and grain boundaries induce the formation of nonregular objects by promoting nonuniform supramolecular crystal growth. Second, the fibrous nanostructures in 2D networks and in 1D bundles firmly support the main body and the spiky projections, respectively. This study also shows that there exist certain connections among entirely disparate entities, that is, organic supramolecular assemblies, inorganic materials, and cells regarding their fundamental principles of building block organizations. The principle behind the CSA formation can be applied to control the dynamic and mechanical properties of self-assembled materials.",

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note = "Funding Information: The authors thank the Korea Basic Science Institute (KBSI) for Cryo-SEM experiments and the Pohang Accelerator Laboratory (PAL) for X-ray diffraction (XRD) experiments. This work was supported by grants from the National Research Foundation (NRF) of Korea (2020R1A2C2007578 and 2022M3E5F1016877). Funding Information: The authors thank the Korea Basic Science Institute (KBSI) for Cryo‐SEM experiments and the Pohang Accelerator Laboratory (PAL) for X‐ray diffraction (XRD) experiments. This work was supported by grants from the National Research Foundation (NRF) of Korea (2020R1A2C2007578 and 2022M3E5F1016877). Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

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Morphogenesis of Cell-Shaped Assemblies via Heterotypic Assembly of Cyclic Triblock Peptides

Abstract

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