Morphological features and pathogenicity of mutated canine influenza viruses from China and South Korea

Woonsung Na, Xing Xie, Minjoo Yeom, Aram Kang, Hyun Ouk Kim, Jong Woo Lim, Geunseon Park, Sun Woo Yoon, Dae Gwin Jeong, Hye Kwon Kim, Seungjoo Haam, Yongjie Liu, Daesub Song

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The canine influenza virus (CIV) has spread globally from East Asia to the United States and mutated and evolved to generate various CIVs. Since 2010, the mutant CIVs found in China and Korea have presented increased virulence in mice, guinea pigs and ferrets, which has raised concerns about public health and outbreak of a severe canine flu. We analysed and compared the morphology, cellular uptake and pathogenicity of CIV variants in host animals, to determine their characteristics. The Chinese mutant, A/canine/Jiangsu/06/2010[H3N2](JS10), has two amino acid insertions at the distal end of the NA stalk, and A/canine/Korea/01/2007[H3N2](KR07) presented comparable efficiency of cell uptake and a similar morphology to spherical or small ovoid particles. However, KR07M generated from swapping of M segment of the pandemic isolate, A/California/04/2009 [H1N1] (CA04) into KR07 alone accounted for morphologic change and higher efficiency of cell uptake to the wild-type CIV. This study will provide an insight into the pathogenesis, transmission and evolution of CIVs and help determine future countermeasures.

Original languageEnglish
Pages (from-to)1607-1613
Number of pages7
JournalTransboundary and Emerging Diseases
Volume67
Issue number4
DOIs
Publication statusPublished - 2020 Jul 1

Bibliographical note

Funding Information:
This research was supported by the National Natural and Science Foundation of China (31800161) and Natural Sciences Foundation of Jiangsu Province (BK20180297), and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2018M3A9H4056339) and by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Animal Disease Management Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (319076-2).

Funding Information:
This research was supported by the National Natural and Science Foundation of China (31800161) and Natural Sciences Foundation of Jiangsu Province (BK20180297), and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF‐2018M3A9H4056339) and by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Animal Disease Management Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (319076‐2).

Publisher Copyright:
© 2020 Blackwell Verlag GmbH

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • veterinary(all)

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