Morphometric abnormality of the insula in schizophrenia: A comparison with obsessive-compulsive disorder and normal control using MRI

Jae Jin Kim, Tak Youn, Jong Min Lee, In Young Kim, Sun I. Kim, Jun Soo Kwon

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The insula is increasingly the subject of great interest in psychiatric disorders of neurodevelopmental origin because of its anatomical location, wide interconnectivity, and variety of functions. This study explores the possible morphometric change of the insula in schizophrenia and obsessive-compulsive disorder (OCD), and its potential relationship to clinical symptoms. The insula was traced on all coronal slices of magnetic resonance images of three age- and sex-matched diagnostic groups, which consisted of 21 patients with schizophrenia, 21 patients with OCD and 21 normal volunteers. The volumetric measures of the insula were compared among the three groups, and their relationships to the symptom severity were investigated. Volumetric reduction of the left insula was observed in the schizophrenia group, but not in the OCD group. These results confirm the involvement of deficient insular function in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalSchizophrenia Research
Volume60
Issue number2-3
DOIs
Publication statusPublished - 2003 Apr 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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