Morphometry of the superior temporal plane in schizophrenia: Relationship to clinical correlates

Benedicto Crespo-Facorro, Jae Jin Kim, Eran Chemerinski, Vincent Magnotta, Nancy C. Andreasen, Peg Nopoulos

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A magnetic-resonance-imaging-based method of cortical parcellation was used to evaluate the morphology of the superior temporal plane and its subregions (Heschl's gyrus [HG], planum temporale [PT], and planum polare [PP]) in a group of 30 patients with schizophrenia versus a matched group of healthy subjects. Right HG volume was significantly reduced in patients compared with control subjects. Each subregion showed a unique set of structure/function relationships: reduced volumes of the HG were associated with greater duration of illness; reduced volumes of the PT were associated with positive symptoms; and in most contrast, elevated volumes of the PP were associated with cumulative neuroleptic exposure.

Original languageEnglish
Pages (from-to)284-294
Number of pages11
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume16
Issue number3
DOIs
Publication statusPublished - 2004 Jan 1

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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