Mortality of patients with bullous pemphigoid in Korea

Ji Hye Lee, Soo Chan Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: The reported mortality rates and prognoses of bullous pemphigoid (BP) vary among different countries. However, the mortality rate of BP has not been investigated in Korea. Objective: We sought to evaluate the mortality rate of Korean patients with BP in comparison to that of an age-matched general population in Korea, and to identify prognostic factors affecting overall survival. Methods: We conducted a retrospective analysis of 168 patients diagnosed with BP between 1993 and 2013 at Gangnam Severance Hospital in Seoul, Korea. Results: The 1-, 2-, and 5-year mortality rates of BP patients were 19.46% (95% confidence interval [CI], 13.83-27.00), 29.13% (95% CI, 21.91-38.08), and 58.03% (95% CI, 47.04-69.45), respectively. The median age was 73 years (range, 6-99 years). The standardized mortality ratio ranged from 2.43 (95% CI, 0.12-11.96) to 9.56 (95% CI, 2.43-26.02), depending on the age group. In multivariate analysis, old age at the time of diagnosis, stroke, diabetes, and delayed diagnosis were associated with increased mortality. Limitations: This study was conducted as a retrospective analysis and was based at a single institution. Conclusion: The mortality rate of patients with BP is significantly higher than that for the general population.

Original languageEnglish
Pages (from-to)676-683
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume71
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Bullous Pemphigoid
Korea
Mortality
Confidence Intervals
Delayed Diagnosis
Population
Multivariate Analysis
Age Groups
Stroke
Survival

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Mortality of patients with bullous pemphigoid in Korea",
abstract = "Background: The reported mortality rates and prognoses of bullous pemphigoid (BP) vary among different countries. However, the mortality rate of BP has not been investigated in Korea. Objective: We sought to evaluate the mortality rate of Korean patients with BP in comparison to that of an age-matched general population in Korea, and to identify prognostic factors affecting overall survival. Methods: We conducted a retrospective analysis of 168 patients diagnosed with BP between 1993 and 2013 at Gangnam Severance Hospital in Seoul, Korea. Results: The 1-, 2-, and 5-year mortality rates of BP patients were 19.46{\%} (95{\%} confidence interval [CI], 13.83-27.00), 29.13{\%} (95{\%} CI, 21.91-38.08), and 58.03{\%} (95{\%} CI, 47.04-69.45), respectively. The median age was 73 years (range, 6-99 years). The standardized mortality ratio ranged from 2.43 (95{\%} CI, 0.12-11.96) to 9.56 (95{\%} CI, 2.43-26.02), depending on the age group. In multivariate analysis, old age at the time of diagnosis, stroke, diabetes, and delayed diagnosis were associated with increased mortality. Limitations: This study was conducted as a retrospective analysis and was based at a single institution. Conclusion: The mortality rate of patients with BP is significantly higher than that for the general population.",
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Mortality of patients with bullous pemphigoid in Korea. / Lee, Ji Hye; Kim, Soo Chan.

In: Journal of the American Academy of Dermatology, Vol. 71, No. 4, 01.01.2014, p. 676-683.

Research output: Contribution to journalArticle

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AB - Background: The reported mortality rates and prognoses of bullous pemphigoid (BP) vary among different countries. However, the mortality rate of BP has not been investigated in Korea. Objective: We sought to evaluate the mortality rate of Korean patients with BP in comparison to that of an age-matched general population in Korea, and to identify prognostic factors affecting overall survival. Methods: We conducted a retrospective analysis of 168 patients diagnosed with BP between 1993 and 2013 at Gangnam Severance Hospital in Seoul, Korea. Results: The 1-, 2-, and 5-year mortality rates of BP patients were 19.46% (95% confidence interval [CI], 13.83-27.00), 29.13% (95% CI, 21.91-38.08), and 58.03% (95% CI, 47.04-69.45), respectively. The median age was 73 years (range, 6-99 years). The standardized mortality ratio ranged from 2.43 (95% CI, 0.12-11.96) to 9.56 (95% CI, 2.43-26.02), depending on the age group. In multivariate analysis, old age at the time of diagnosis, stroke, diabetes, and delayed diagnosis were associated with increased mortality. Limitations: This study was conducted as a retrospective analysis and was based at a single institution. Conclusion: The mortality rate of patients with BP is significantly higher than that for the general population.

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