Mortality risk factors for patients with septic shock after implementation of the surviving sepsis campaign bundles

Je Eun Song, Moo Hyun Kim, Woo Yong Jeong, In Young Jung, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, June Myung Kim, Jun Yong Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Septic shock remains a leading cause of death, despite advances in critical care management. The Surviving Sepsis Campaign (SSC) has reduced morbidity and mortality. This study evaluated risk factors for mortality in patients with septic shock who received treatment following the SSC bundles. Materials and Methods: This retrospective cohort study included patients with septic shock who received treatments following SSC bundles in an urban emergency department between November 2007 and November 2011. Primary and secondary endpoints were all-cause 7- and 28-day mortality. Results: Among 436 patients, 7- and 28-day mortality rates were 7.11% (31/436) and 14% (61/436), respectively. In multivariate analysis, high lactate level (odds ratio [OR], 1.286; 95% confidence interval [CI], 1.016-1.627; P = 0.036) and low estimated glomerular filtration rate (OR, 0.953; 95% CI, 0.913-0.996; P = 0.032) were independent risk factors for 7-day mortality. Risk factors for 28-day mortality were high lactate level (OR, 1.346; 95% CI, 1.083-1.673; P = 0.008) and high Acute Physiology and Chronic Health Evaluation II score (OR, 1.153; 95% CI, 1.029-1.293; P = 0.014). Conclusion: The risk of mortality of septic shock patients remains high in patients with high lactate levels and acute kidney injury.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalInfection and Chemotherapy
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

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Septic Shock
Sepsis
Mortality
Odds Ratio
Confidence Intervals
Lactic Acid
APACHE
Critical Care
Glomerular Filtration Rate
Acute Kidney Injury
Hospital Emergency Service
Cause of Death
Cohort Studies
Multivariate Analysis
Retrospective Studies
Morbidity
Therapeutics

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Song, Je Eun ; Kim, Moo Hyun ; Jeong, Woo Yong ; Jung, In Young ; Oh, Dong Hyun ; Kim, Yong Chan ; Kim, Eun Jin ; Jeong, Su Jin ; Ku, Nam Su ; Kim, June Myung ; Choi, Jun Yong. / Mortality risk factors for patients with septic shock after implementation of the surviving sepsis campaign bundles. In: Infection and Chemotherapy. 2016 ; Vol. 48, No. 3. pp. 199-208.
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abstract = "Background: Septic shock remains a leading cause of death, despite advances in critical care management. The Surviving Sepsis Campaign (SSC) has reduced morbidity and mortality. This study evaluated risk factors for mortality in patients with septic shock who received treatment following the SSC bundles. Materials and Methods: This retrospective cohort study included patients with septic shock who received treatments following SSC bundles in an urban emergency department between November 2007 and November 2011. Primary and secondary endpoints were all-cause 7- and 28-day mortality. Results: Among 436 patients, 7- and 28-day mortality rates were 7.11{\%} (31/436) and 14{\%} (61/436), respectively. In multivariate analysis, high lactate level (odds ratio [OR], 1.286; 95{\%} confidence interval [CI], 1.016-1.627; P = 0.036) and low estimated glomerular filtration rate (OR, 0.953; 95{\%} CI, 0.913-0.996; P = 0.032) were independent risk factors for 7-day mortality. Risk factors for 28-day mortality were high lactate level (OR, 1.346; 95{\%} CI, 1.083-1.673; P = 0.008) and high Acute Physiology and Chronic Health Evaluation II score (OR, 1.153; 95{\%} CI, 1.029-1.293; P = 0.014). Conclusion: The risk of mortality of septic shock patients remains high in patients with high lactate levels and acute kidney injury.",
author = "Song, {Je Eun} and Kim, {Moo Hyun} and Jeong, {Woo Yong} and Jung, {In Young} and Oh, {Dong Hyun} and Kim, {Yong Chan} and Kim, {Eun Jin} and Jeong, {Su Jin} and Ku, {Nam Su} and Kim, {June Myung} and Choi, {Jun Yong}",
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Song, JE, Kim, MH, Jeong, WY, Jung, IY, Oh, DH, Kim, YC, Kim, EJ, Jeong, SJ, Ku, NS, Kim, JM & Choi, JY 2016, 'Mortality risk factors for patients with septic shock after implementation of the surviving sepsis campaign bundles', Infection and Chemotherapy, vol. 48, no. 3, pp. 199-208. https://doi.org/10.3947/ic.2016.48.3.199

Mortality risk factors for patients with septic shock after implementation of the surviving sepsis campaign bundles. / Song, Je Eun; Kim, Moo Hyun; Jeong, Woo Yong; Jung, In Young; Oh, Dong Hyun; Kim, Yong Chan; Kim, Eun Jin; Jeong, Su Jin; Ku, Nam Su; Kim, June Myung; Choi, Jun Yong.

In: Infection and Chemotherapy, Vol. 48, No. 3, 01.01.2016, p. 199-208.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mortality risk factors for patients with septic shock after implementation of the surviving sepsis campaign bundles

AU - Song, Je Eun

AU - Kim, Moo Hyun

AU - Jeong, Woo Yong

AU - Jung, In Young

AU - Oh, Dong Hyun

AU - Kim, Yong Chan

AU - Kim, Eun Jin

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Kim, June Myung

AU - Choi, Jun Yong

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Septic shock remains a leading cause of death, despite advances in critical care management. The Surviving Sepsis Campaign (SSC) has reduced morbidity and mortality. This study evaluated risk factors for mortality in patients with septic shock who received treatment following the SSC bundles. Materials and Methods: This retrospective cohort study included patients with septic shock who received treatments following SSC bundles in an urban emergency department between November 2007 and November 2011. Primary and secondary endpoints were all-cause 7- and 28-day mortality. Results: Among 436 patients, 7- and 28-day mortality rates were 7.11% (31/436) and 14% (61/436), respectively. In multivariate analysis, high lactate level (odds ratio [OR], 1.286; 95% confidence interval [CI], 1.016-1.627; P = 0.036) and low estimated glomerular filtration rate (OR, 0.953; 95% CI, 0.913-0.996; P = 0.032) were independent risk factors for 7-day mortality. Risk factors for 28-day mortality were high lactate level (OR, 1.346; 95% CI, 1.083-1.673; P = 0.008) and high Acute Physiology and Chronic Health Evaluation II score (OR, 1.153; 95% CI, 1.029-1.293; P = 0.014). Conclusion: The risk of mortality of septic shock patients remains high in patients with high lactate levels and acute kidney injury.

AB - Background: Septic shock remains a leading cause of death, despite advances in critical care management. The Surviving Sepsis Campaign (SSC) has reduced morbidity and mortality. This study evaluated risk factors for mortality in patients with septic shock who received treatment following the SSC bundles. Materials and Methods: This retrospective cohort study included patients with septic shock who received treatments following SSC bundles in an urban emergency department between November 2007 and November 2011. Primary and secondary endpoints were all-cause 7- and 28-day mortality. Results: Among 436 patients, 7- and 28-day mortality rates were 7.11% (31/436) and 14% (61/436), respectively. In multivariate analysis, high lactate level (odds ratio [OR], 1.286; 95% confidence interval [CI], 1.016-1.627; P = 0.036) and low estimated glomerular filtration rate (OR, 0.953; 95% CI, 0.913-0.996; P = 0.032) were independent risk factors for 7-day mortality. Risk factors for 28-day mortality were high lactate level (OR, 1.346; 95% CI, 1.083-1.673; P = 0.008) and high Acute Physiology and Chronic Health Evaluation II score (OR, 1.153; 95% CI, 1.029-1.293; P = 0.014). Conclusion: The risk of mortality of septic shock patients remains high in patients with high lactate levels and acute kidney injury.

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