MoSe2 Nanolabels for Electrochemical Immunoassays

Rou Jun Toh, Carmen C. Mayorga-Martinez, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticle

18 Citations (Scopus)


There is huge interest in biosensors as a result of the demand for personalized medicine. In biomolecular detection, transition-metal dichalcogenides (TMDs) can be used as signal-enhancing elements. Herein, we utilize a solution-based electrochemical exfoliation technique with bipolar electrodes to manufacture MoSe2 nanolabels for biomolecular detection. Prepared MoSe2 nanoparticles (NPs) exhibit electrocatalytic activity toward the hydrogen evolution reaction (HER), and such a property allows it to act as a robust label for magneto-immunoassays toward protein detection. The magneto-immunoassay also displayed good selectivity, a wide linear range of 2 to 500 ng mL-1, high sensitivity (LOD = 1.23 ng mL-1) and reproducibility (RSD = 9.7%). These findings establish the viability and reproducibility of such an exfoliation technique for TMD nanolabels for the development of low costs and efficient biosensing systems. (Graph Presented).

Original languageEnglish
Pages (from-to)12204-12209
Number of pages6
JournalAnalytical Chemistry
Issue number24
Publication statusPublished - 2016 Dec 20

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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