MoS2 exhibits stronger toxicity with increased exfoliation

Elaine Lay Khim Chng, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

MoS2 belong to a class of inorganic 2D nanomaterials known as transition metal dichalcogenides (TMDs) which have recently attracted a renewed and growing interest due to their interesting electronic and catalytic properties when scaled down to single or few layer sheets. Although exfoliated MoS2 nanosheets have been proposed for numerous energy-related and biosensing applications, little is known about the toxicological impacts of using MoS2 nanosheets. Here, we report about the in vitro toxicity of MoS2 nanosheets that have been chemically exfoliated with di fferent lithium intercalating agents and compared their respective cytotoxic influence. Methyllithium (Me-Li), n-butyllithium (n-Bu-Li) and tert-butyllithium (t-Bu-Li) were used for the exfoliation of bulk MoS2 and we found the t-Bu-Li and n-Bu-Li exfoliated MoS2 nanosheets to be more cytotoxic than MoS2 exfoliated by Me-Li. t-Bu-Li and n-Bu-Li provide more efficient exfoliation over Me-Li, and we establish that the extent of exfoliation that MoS2 undergo is a factor influencing their toxicity. Specifically, the more exfoliated the MoS2 nanosheets, the stronger its cytotoxic influence, which may be due to an increase in surface area and active edge sites. The potential toxicity of these MoS2 nanosheets should be taken into account before their employment in real world applications and we have shown the effect the amount of exfoliation can have on the toxicity of MoS2 nanosheets, representing the first step towards a better understanding of their toxicological properties.

Original languageEnglish
Pages (from-to)14412-14418
Number of pages7
JournalNanoscale
Volume6
Issue number23
DOIs
Publication statusPublished - 2014 Dec 7

Fingerprint

Nanosheets
Toxicity
Intercalating Agents
Lithium
Nanostructured materials
Transition metals
n-butyllithium

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Chng, Elaine Lay Khim ; Sofer, Zdeněk ; Pumera, Martin. / MoS2 exhibits stronger toxicity with increased exfoliation. In: Nanoscale. 2014 ; Vol. 6, No. 23. pp. 14412-14418.
@article{98c77d9c920945b2a6c29bc5055f8902,
title = "MoS2 exhibits stronger toxicity with increased exfoliation",
abstract = "MoS2 belong to a class of inorganic 2D nanomaterials known as transition metal dichalcogenides (TMDs) which have recently attracted a renewed and growing interest due to their interesting electronic and catalytic properties when scaled down to single or few layer sheets. Although exfoliated MoS2 nanosheets have been proposed for numerous energy-related and biosensing applications, little is known about the toxicological impacts of using MoS2 nanosheets. Here, we report about the in vitro toxicity of MoS2 nanosheets that have been chemically exfoliated with di fferent lithium intercalating agents and compared their respective cytotoxic influence. Methyllithium (Me-Li), n-butyllithium (n-Bu-Li) and tert-butyllithium (t-Bu-Li) were used for the exfoliation of bulk MoS2 and we found the t-Bu-Li and n-Bu-Li exfoliated MoS2 nanosheets to be more cytotoxic than MoS2 exfoliated by Me-Li. t-Bu-Li and n-Bu-Li provide more efficient exfoliation over Me-Li, and we establish that the extent of exfoliation that MoS2 undergo is a factor influencing their toxicity. Specifically, the more exfoliated the MoS2 nanosheets, the stronger its cytotoxic influence, which may be due to an increase in surface area and active edge sites. The potential toxicity of these MoS2 nanosheets should be taken into account before their employment in real world applications and we have shown the effect the amount of exfoliation can have on the toxicity of MoS2 nanosheets, representing the first step towards a better understanding of their toxicological properties.",
author = "Chng, {Elaine Lay Khim} and Zdeněk Sofer and Martin Pumera",
year = "2014",
month = "12",
day = "7",
doi = "10.1039/c4nr04907a",
language = "English",
volume = "6",
pages = "14412--14418",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "23",

}

MoS2 exhibits stronger toxicity with increased exfoliation. / Chng, Elaine Lay Khim; Sofer, Zdeněk; Pumera, Martin.

In: Nanoscale, Vol. 6, No. 23, 07.12.2014, p. 14412-14418.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MoS2 exhibits stronger toxicity with increased exfoliation

AU - Chng, Elaine Lay Khim

AU - Sofer, Zdeněk

AU - Pumera, Martin

PY - 2014/12/7

Y1 - 2014/12/7

N2 - MoS2 belong to a class of inorganic 2D nanomaterials known as transition metal dichalcogenides (TMDs) which have recently attracted a renewed and growing interest due to their interesting electronic and catalytic properties when scaled down to single or few layer sheets. Although exfoliated MoS2 nanosheets have been proposed for numerous energy-related and biosensing applications, little is known about the toxicological impacts of using MoS2 nanosheets. Here, we report about the in vitro toxicity of MoS2 nanosheets that have been chemically exfoliated with di fferent lithium intercalating agents and compared their respective cytotoxic influence. Methyllithium (Me-Li), n-butyllithium (n-Bu-Li) and tert-butyllithium (t-Bu-Li) were used for the exfoliation of bulk MoS2 and we found the t-Bu-Li and n-Bu-Li exfoliated MoS2 nanosheets to be more cytotoxic than MoS2 exfoliated by Me-Li. t-Bu-Li and n-Bu-Li provide more efficient exfoliation over Me-Li, and we establish that the extent of exfoliation that MoS2 undergo is a factor influencing their toxicity. Specifically, the more exfoliated the MoS2 nanosheets, the stronger its cytotoxic influence, which may be due to an increase in surface area and active edge sites. The potential toxicity of these MoS2 nanosheets should be taken into account before their employment in real world applications and we have shown the effect the amount of exfoliation can have on the toxicity of MoS2 nanosheets, representing the first step towards a better understanding of their toxicological properties.

AB - MoS2 belong to a class of inorganic 2D nanomaterials known as transition metal dichalcogenides (TMDs) which have recently attracted a renewed and growing interest due to their interesting electronic and catalytic properties when scaled down to single or few layer sheets. Although exfoliated MoS2 nanosheets have been proposed for numerous energy-related and biosensing applications, little is known about the toxicological impacts of using MoS2 nanosheets. Here, we report about the in vitro toxicity of MoS2 nanosheets that have been chemically exfoliated with di fferent lithium intercalating agents and compared their respective cytotoxic influence. Methyllithium (Me-Li), n-butyllithium (n-Bu-Li) and tert-butyllithium (t-Bu-Li) were used for the exfoliation of bulk MoS2 and we found the t-Bu-Li and n-Bu-Li exfoliated MoS2 nanosheets to be more cytotoxic than MoS2 exfoliated by Me-Li. t-Bu-Li and n-Bu-Li provide more efficient exfoliation over Me-Li, and we establish that the extent of exfoliation that MoS2 undergo is a factor influencing their toxicity. Specifically, the more exfoliated the MoS2 nanosheets, the stronger its cytotoxic influence, which may be due to an increase in surface area and active edge sites. The potential toxicity of these MoS2 nanosheets should be taken into account before their employment in real world applications and we have shown the effect the amount of exfoliation can have on the toxicity of MoS2 nanosheets, representing the first step towards a better understanding of their toxicological properties.

UR - http://www.scopus.com/inward/record.url?scp=84908873237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908873237&partnerID=8YFLogxK

U2 - 10.1039/c4nr04907a

DO - 10.1039/c4nr04907a

M3 - Article

C2 - 25341082

AN - SCOPUS:84908873237

VL - 6

SP - 14412

EP - 14418

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 23

ER -