Motor Cerebellar Connectivity and Future Development of Freezing of Gait in De Novo Parkinson's Disease

Jin Ho Jung, Bo Hyun Kim, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Byoung Seok Ye, Young H. Sohn, Jong Min Lee, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective: To investigate the role of motor cerebellar connectivity in future development of freezing of gait, because it is a complex network disorder in Parkinson's disease (PD). Methods: We recruited 26 de novo patients with PD who experienced freezing of gait within 5 years from magnetic resonance imaging acquisition (vulnerable PD group), 61 patients with PD who had not experienced freezing of gait within 5 years (resistant PD group), and 27 healthy control subjects. We compared the resting state functional connectivity between the motor cerebellum and the whole brain between the groups. In addition, we evaluated the relationship between motor cerebellar connectivity and freezing of gait latency. Results: The vulnerable PD group had increased functional connectivity between the motor cerebellum and parieto-occipito-temporal association cortices compared with the control group or the resistant PD group. Connectivity between lobule VI and the right superior parietal lobule, right fusiform gyrus, and left inferior temporal gyrus; between lobule VIIb and the right superior parietal lobule, right hippocampus, and right middle temporal gyrus; and between lobule VIIIb and the bilateral fusiform gyri, right middle occipital gyrus, and bilateral parietal lobes was inversely proportional to freezing of gait latency. The freezing of gait latency-related cortical functional connectivity from the motor cerebellum was also significantly higher in the vulnerable PD group compared with the control group, as well as the resistant PD group. Conclusions: The data suggest that the motor cerebellar functional connectivity with the posterior cortical areas play an important role in future development of freezing of gait in PD.

Original languageEnglish
Pages (from-to)2240-2249
Number of pages10
JournalMovement Disorders
Volume35
Issue number12
DOIs
Publication statusPublished - 2020 Dec

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (grant NRF‐2019R1A2C2085462), and the NRF funded by the Korean government (MSIT; grant NRF‐2019R1H1A2101514). P.H.L. receives funding from NRF‐2019R1A2C2085462, and J.M.L. receives funding from NRF‐2019R1H1A2101514.

Funding Information:
P.H.L. and J.‐M.L. were the recipients of grants from the National Research Foundation of Korea (NRF‐2019R1A2C2085462 and NRF‐2019R1H1A2101514, respectively).

Publisher Copyright:
© 2020 International Parkinson and Movement Disorder Society

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Motor Cerebellar Connectivity and Future Development of Freezing of Gait in De Novo Parkinson's Disease'. Together they form a unique fingerprint.

Cite this