MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner

Eun Ju Kim, Kiyoung Jeong, Seung Jae Oh, Daehong Kim, Eun Hae Park, Young Han Lee, Jinsuck Suh

Research output: Contribution to journalArticle

Abstract

Magnetic resonance (MR) thermometry is a noninvasive method for monitoring local temperature change during thermal therapy. In this study, a MR temperature analysis program was established for a laser with gold nanorods (GNRs) and high-intensity focused ultrasound (HIFU)-induced heating MR thermometry. The MR temperature map was reconstructed using the water proton resonance frequency (PRF) method. The temperature-sensitive phase difference was acquired by using complex number subtraction instead of direct phase subtraction in order to avoid another phase unwrapping process. A temperature map-analyzing program was developed and implemented in IDL (Interactive Data Language) for effective temperature monitoring. This one program was applied to two different heating devices at a clinical MR scanner. All images were acquired with the fast spoiled gradient echo (fSPGR) pulse sequence on a 3.0 T GE Discovery MR750 scanner with an 8-channel knee array coil or with a home-built small surface coil. The analyzed temperature values were confirmed by using values simultaneously measured with an optical temperature probe (R2 = 0.996). The temperature change in small samples induced by a laser or by HIFU was analyzed by using a raw data, that consisted of complex numbers. This study shows that our MR thermometry analysis program can be used for thermal therapy study with a laser or HIFU at a clinical MR scanner. It can also be applied to temperature monitoring for any other thermal therapy based on the PRF method.

Original languageEnglish
Pages (from-to)2126-2131
Number of pages6
JournalJournal of the Korean Physical Society
Volume65
Issue number12
DOIs
Publication statusPublished - 2014 Jan 1

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scanners
magnetic resonance
temperature measurement
heating
lasers
complex numbers
temperature
proton resonance
therapy
subtraction
coils
temperature probes
nanorods
echoes
gold
gradients
pulses
water

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Kim, Eun Ju ; Jeong, Kiyoung ; Oh, Seung Jae ; Kim, Daehong ; Park, Eun Hae ; Lee, Young Han ; Suh, Jinsuck. / MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner. In: Journal of the Korean Physical Society. 2014 ; Vol. 65, No. 12. pp. 2126-2131.
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MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner. / Kim, Eun Ju; Jeong, Kiyoung; Oh, Seung Jae; Kim, Daehong; Park, Eun Hae; Lee, Young Han; Suh, Jinsuck.

In: Journal of the Korean Physical Society, Vol. 65, No. 12, 01.01.2014, p. 2126-2131.

Research output: Contribution to journalArticle

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