Abstract
BACKGROUND AND PURPOSE: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease-related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease-related cognitive impairment and β-amyloid deposition, assessed with [18F] florbetaben PET/CT. MATERIALS AND METHODS: MR imaging and [18F] florbetaben PET/CT images of 144 patients with Alzheimer disease-related cognitive impairment were retrospectively evaluated. MR imaging-visible perivascular spaces were rated on a 4-point visual scale: A score of ≥3 or ,3 indicated a high or low degree of MR imaging-visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β -amyloid plaque load scoring system. RESULTS: Compared with patients negative for β -amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the Apolipoprotein E 4 allele, and a high degree of MR imaging-visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and Apolipoprotein E status, revealed that a high degree of MR imaging-visible perivascular spaces in the centrum semiovale was independently associated with β -amyloid positivity (odds ratio, 2.307; 95% CI, 1.036-5.136; P=.041). CONCLUSIONS: A high degree of MR imaging-visible perivascular spaces in the centrum semiovale independently predicted β -amyloid positivity in patients with Alzheimer disease-related cognitive impairment. Thus, MR imaging-visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease-related cognitive impairment.
| Original language | English |
|---|---|
| Pages (from-to) | 1231-1238 |
| Number of pages | 8 |
| Journal | American Journal of Neuroradiology |
| Volume | 42 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2021 Jul 1 |
Bibliographical note
Funding Information:Received June 18, 2020; accepted after revision January 21, 2021. From the Departments of Nuclear Medicine (H.J.K., Y.H.R.), Neurology (H.C., C.H.L.), and Radiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; and Department of Nuclear Medicine (H.J.K.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea. H.J. Kim and H. Cho contributed equally to this work. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2017R1D1A1B03034388), the National Research Foundation of Korea grant funded by the Korean government (Ministry of Science and ICT) (No. NRF-2020R1C1C1005724), and Yonsei University College of Medicine (6-2019-0059). Please address correspondence to Mina Park, MD, Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Eonjuro 211, Gangnam-gu, Seoul, South Korea; e-mail: to.minapark@yuhs.ac
Publisher Copyright:
© 2021 American Society of Neuroradiology. All rights reserved.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Clinical Neurology