MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee, Jane Melissa Lim, Hyunchu Cho, Eunju Kim, Yeonsil Kim, Hye Kyung Oh, Woo Seok Yang, Kyung Hye Roh, Hyun Woo Park, Jung Soon Mo, Je Hyun Yoon, Hyun Kyu Song, Eui Ju Choi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

Original languageEnglish
Pages (from-to)1138-1149.e6
JournalMolecular Cell
Issue number6
Publication statusPublished - 2019 Mar 21

Bibliographical note

Funding Information:
We thank K. Iwai for GST-hTNFα(77–233) cDNA, S. Yonehara for Flag-MST1 cDNA, V.M. Dixit for antibody to linear ubiquitin, S.Y. Lee for TRAF2 +/+ or TRAF2 − / − MEFs, and D.S. Lim for MST1 − / − mice. This work was supported by a National Research Foundation grant ( NRF-2017R1A2B2008193 ) and by a BRL grant ( NRF-2015R1A4A1041919 ) funded by the Ministry of Science and ICT of Korea as well as by a Korea University grant (E.-J.C.).

Publisher Copyright:
© 2019 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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