MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee; Jane Melissa Lim; Hyunchu Cho; Eunju Kim; Yeonsil Kim; Hye Kyung Oh; Woo Seok Yang; Kyung Hye Roh; Hyun Woo Park; Jung Soon Mo; Je Hyun Yoon; Hyun Kyu Song; Eui Ju Choi

doi:10.1016/j.molcel.2019.01.022

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee, Jane Melissa Lim, Hyunchu Cho, Eunju Kim, Yeonsil Kim, Hye Kyung Oh, Woo Seok Yang, Kyung Hye Roh, Hyun Woo Park, Jung Soon Mo, Je Hyun Yoon, Hyun Kyu Song, Eui Ju Choi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

Original language	English
Pages (from-to)	1138-1149.e6
Journal	Molecular Cell
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.01.022
Publication status	Published - 2019 Mar 21

Bibliographical note

Funding Information:
We thank K. Iwai for GST-hTNFα(77–233) cDNA, S. Yonehara for Flag-MST1 cDNA, V.M. Dixit for antibody to linear ubiquitin, S.Y. Lee for TRAF2 +/+ or TRAF2 − / − MEFs, and D.S. Lim for MST1 − / − mice. This work was supported by a National Research Foundation grant ( NRF-2017R1A2B2008193 ) and by a BRL grant ( NRF-2015R1A4A1041919 ) funded by the Ministry of Science and ICT of Korea as well as by a Korea University grant (E.-J.C.).

Publisher Copyright:
© 2019 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.01.022

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title = "MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity",

abstract = "Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.",

author = "Lee, {In Young} and Lim, {Jane Melissa} and Hyunchu Cho and Eunju Kim and Yeonsil Kim and Oh, {Hye Kyung} and Yang, {Woo Seok} and Roh, {Kyung Hye} and Park, {Hyun Woo} and Mo, {Jung Soon} and Yoon, {Je Hyun} and Song, {Hyun Kyu} and Choi, {Eui Ju}",

note = "Funding Information: We thank K. Iwai for GST-hTNFα(77–233) cDNA, S. Yonehara for Flag-MST1 cDNA, V.M. Dixit for antibody to linear ubiquitin, S.Y. Lee for TRAF2 +/+ or TRAF2 − / − MEFs, and D.S. Lim for MST1 − / − mice. This work was supported by a National Research Foundation grant ( NRF-2017R1A2B2008193 ) and by a BRL grant ( NRF-2015R1A4A1041919 ) funded by the Ministry of Science and ICT of Korea as well as by a Korea University grant (E.-J.C.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.molcel.2019.01.022",

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MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. / Lee, In Young; Lim, Jane Melissa; Cho, Hyunchu; Kim, Eunju; Kim, Yeonsil; Oh, Hye Kyung; Yang, Woo Seok; Roh, Kyung Hye; Park, Hyun Woo; Mo, Jung Soon; Yoon, Je Hyun; Song, Hyun Kyu; Choi, Eui Ju.

In: Molecular Cell, Vol. 73, No. 6, 21.03.2019, p. 1138-1149.e6.

Research output: Contribution to journal › Article › peer-review

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AU - Lee, In Young

AU - Lim, Jane Melissa

AU - Cho, Hyunchu

AU - Kim, Eunju

AU - Kim, Yeonsil

AU - Oh, Hye Kyung

AU - Yang, Woo Seok

AU - Roh, Kyung Hye

AU - Park, Hyun Woo

AU - Mo, Jung Soon

AU - Yoon, Je Hyun

AU - Song, Hyun Kyu

AU - Choi, Eui Ju

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PY - 2019/3/21

Y1 - 2019/3/21

N2 - Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

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MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

Abstract

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