Mucinous carcinoma with extensive signet ring cell differentiation: A case report

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin. In a case with signet ring cell differentiation, differential diagnosis with metastatic signet ring cell carcinoma of the stomach and colon is essential. In this case, the presence of accompanied ductal carcinoma in situ component and mammaglobin and gross cystic disease fluid protein-15 positivity were findings that suggested the breast as the origin.

Original languageEnglish
Pages (from-to)176-179
Number of pages4
JournalJournal of Pathology and Translational Medicine
Volume51
Issue number2
DOIs
Publication statusPublished - 2017 Jan 1

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Mucinous Adenocarcinoma
Mucins
Cell Differentiation
Signet Ring Cell Carcinoma
Breast Neoplasms
Mitotic Index
Carcinoma, Intraductal, Noninfiltrating
Progesterone Receptors
Cadherins
Estrogen Receptors
Stomach
Colon
Breast
Differential Diagnosis
Carcinoma
Proteins

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

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abstract = "Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin. In a case with signet ring cell differentiation, differential diagnosis with metastatic signet ring cell carcinoma of the stomach and colon is essential. In this case, the presence of accompanied ductal carcinoma in situ component and mammaglobin and gross cystic disease fluid protein-15 positivity were findings that suggested the breast as the origin.",
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Mucinous carcinoma with extensive signet ring cell differentiation : A case report. / Kim, Hye Min; Kim, Eunkyung; Koo, JaSeung.

In: Journal of Pathology and Translational Medicine, Vol. 51, No. 2, 01.01.2017, p. 176-179.

Research output: Contribution to journalArticle

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