Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease.

Sun Mie Yim, Duk Hwan Kim, Hyun Jung Lee, Hui Won Jang, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Behçet's disease (BD). We investigated whether MH could predict the prognosis of intestinal BD. We retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan-Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD. The number of patients with active ulcers at the time of clinical remission was 57 (71.3%), while 23 patients (28.7%) were experiencing MH. In the active ulcer group, 39 patients (68.4%) experienced recurrence during the follow-up period, whereas 7 patients (30.4%) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse. Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.

Original languageEnglish
Pages (from-to)2529-2535
Number of pages7
JournalDigestive diseases and sciences
Volume59
Issue number10
DOIs
Publication statusPublished - 2014 Oct

Fingerprint

Intestinal Diseases
Ulcer
Recurrence
Multivariate Analysis
Colonoscopy
Therapeutics
Inflammatory Bowel Diseases
Proportional Hazards Models
Medical Records

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Yim, Sun Mie ; Kim, Duk Hwan ; Lee, Hyun Jung ; Jang, Hui Won ; Park, Soo Jung ; Hong, Sung Pil ; Kim, Tae Il ; Kim, Won Ho ; Cheon, Jae Hee. / Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease. In: Digestive diseases and sciences. 2014 ; Vol. 59, No. 10. pp. 2529-2535.
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abstract = "Mucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Beh{\cc}et's disease (BD). We investigated whether MH could predict the prognosis of intestinal BD. We retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan-Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD. The number of patients with active ulcers at the time of clinical remission was 57 (71.3{\%}), while 23 patients (28.7{\%}) were experiencing MH. In the active ulcer group, 39 patients (68.4{\%}) experienced recurrence during the follow-up period, whereas 7 patients (30.4{\%}) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse. Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.",
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Yim, SM, Kim, DH, Lee, HJ, Jang, HW, Park, SJ, Hong, SP, Kim, TI, Kim, WH & Cheon, JH 2014, 'Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease.', Digestive diseases and sciences, vol. 59, no. 10, pp. 2529-2535. https://doi.org/10.1007/s10620-014-3198-z

Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease. / Yim, Sun Mie; Kim, Duk Hwan; Lee, Hyun Jung; Jang, Hui Won; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, Jae Hee.

In: Digestive diseases and sciences, Vol. 59, No. 10, 10.2014, p. 2529-2535.

Research output: Contribution to journalArticle

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AU - Cheon, Jae Hee

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