Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer

Analysis of survival data from high-volume Eastern centers and the SEER database

Taeil Son, Jiyu Sun, Seohee Choi, Minah Cho, In Gyu Kwon, Hyoung Il Kim, Jae Ho Cheong, Seung Ho Choi, Sung Hoon Noh, Yanghee Woo, Yuman Fong, Sohee Park, WooJin Hyung

Research output: Contribution to journalArticle

Abstract

Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

Original languageEnglish
Pages (from-to)676-684
Number of pages9
JournalJournal of surgical oncology
Volume120
Issue number4
DOIs
Publication statusPublished - 2019 Jan 1

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Neoplasm Staging
Survival Analysis
Stomach Neoplasms
Epidemiology
Databases
Survival
Korea
Stomach
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Son, Taeil ; Sun, Jiyu ; Choi, Seohee ; Cho, Minah ; Kwon, In Gyu ; Kim, Hyoung Il ; Cheong, Jae Ho ; Choi, Seung Ho ; Noh, Sung Hoon ; Woo, Yanghee ; Fong, Yuman ; Park, Sohee ; Hyung, WooJin. / Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer : Analysis of survival data from high-volume Eastern centers and the SEER database. In: Journal of surgical oncology. 2019 ; Vol. 120, No. 4. pp. 676-684.
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abstract = "Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.",
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Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer : Analysis of survival data from high-volume Eastern centers and the SEER database. / Son, Taeil; Sun, Jiyu; Choi, Seohee; Cho, Minah; Kwon, In Gyu; Kim, Hyoung Il; Cheong, Jae Ho; Choi, Seung Ho; Noh, Sung Hoon; Woo, Yanghee; Fong, Yuman; Park, Sohee; Hyung, WooJin.

In: Journal of surgical oncology, Vol. 120, No. 4, 01.01.2019, p. 676-684.

Research output: Contribution to journalArticle

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T1 - Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer

T2 - Analysis of survival data from high-volume Eastern centers and the SEER database

AU - Son, Taeil

AU - Sun, Jiyu

AU - Choi, Seohee

AU - Cho, Minah

AU - Kwon, In Gyu

AU - Kim, Hyoung Il

AU - Cheong, Jae Ho

AU - Choi, Seung Ho

AU - Noh, Sung Hoon

AU - Woo, Yanghee

AU - Fong, Yuman

AU - Park, Sohee

AU - Hyung, WooJin

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Y1 - 2019/1/1

N2 - Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

AB - Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

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