Multi-Scale Conditional Generative Adversarial Network for Small-Sized Lung Nodules Using Class Activation Region Influence Maximization

Kyeongjin Ann, Yeonggul Jang, Hackjoon Shim, Hyuk Jae Chang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Automatic detection and classification of thoracic diseases using deep learning algorithms have many applications supporting radiologists' diagnosis and prognosis. However, in the medical field, the class-imbalanced problem is extremely common due to the differences in prevalence among diseases, making it difficult to develop these applications. Many GAN-based methods have been proposed to solve the class-imbalance problem on chest X-ray (CXR) data. However, these models have not been trained well for small-sized diseases because it is challenging to extract sufficient information with only a few pixels. In this paper, we propose a novel deep generative model called a class activation region influence maximization conditional generative adversarial network (CARIM-cGAN). The proposed network can control the target disease's presence, location, and size with a controllable conditional mask. We newly introduced class activation region influence maximization (CARIM) loss to maximize the probability of disease occurrence in the bounded region represented by a conditional mask. To demonstrate an enhanced generative performance, we conducted numerous qualitative and quantitative evaluations with the samples generated using a CARIM-cGAN. The results showed that our method has a better performance than other methods. In conclusion, because the CARIM-cGAN can generate high-quality samples based on information on the location and size of the disease, we can contribute to solving problems such as disease classification,-detection, and-localization, requiring a higher annotation cost.

Original languageEnglish
Pages (from-to)139426-139437
Number of pages12
JournalIEEE Access
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2013 IEEE.

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Materials Science(all)
  • Engineering(all)
  • Electrical and Electronic Engineering


Dive into the research topics of 'Multi-Scale Conditional Generative Adversarial Network for Small-Sized Lung Nodules Using Class Activation Region Influence Maximization'. Together they form a unique fingerprint.

Cite this