Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)

Seok J. Kim, Chul W. Choi, Yeung Chul Mun, Sung Y. Oh, Hye J. Kang, Soon I. Lee, Jong H. Won, Min K. Kim, Jung H. Kwon, Jin S. Kim, Jae Yong Kwak, Jung M. Kwon, In G. Hwang, Hyo J. Kim, Jae H. Lee, Sukjoong Oh, Keon W. Park, Cheolwon Suh, Won S. Kim

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Abstract

Background: Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are warranted.Methods: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes.Results: B-cell lymphoma (n = 504, 86.7%) was more frequent than T-cell lymphoma (n = 77, 13.3%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4%), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5%). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28% versus 71%, P < 0.001). B symptoms were relatively uncommon (20.7%), and bone marrow invasion was a rare event (7.4%). The ileocecal region was the most commonly involved site (39.8%), followed by the small (27.9%) and large intestines (21.5%). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77% versus 57%, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72%) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status ≥ 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival.Conclusions: The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection.

Original languageEnglish
Article number321
JournalBMC cancer
Volume11
DOIs
Publication statusPublished - 2011 Jul 29

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Non-Hodgkin's Lymphoma
T-Cell Lymphoma
Lymphoma
B-Cell Lymphoma
Marginal Zone B-Cell Lymphoma
Survival
Lymphoma, Large B-Cell, Diffuse
Korea
L-Lactate Dehydrogenase
Survival Rate
T-Lymphocytes
Phenotype
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

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Kim, Seok J. ; Choi, Chul W. ; Mun, Yeung Chul ; Oh, Sung Y. ; Kang, Hye J. ; Lee, Soon I. ; Won, Jong H. ; Kim, Min K. ; Kwon, Jung H. ; Kim, Jin S. ; Kwak, Jae Yong ; Kwon, Jung M. ; Hwang, In G. ; Kim, Hyo J. ; Lee, Jae H. ; Oh, Sukjoong ; Park, Keon W. ; Suh, Cheolwon ; Kim, Won S. / Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL). In: BMC cancer. 2011 ; Vol. 11.
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title = "Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)",
abstract = "Background: Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are warranted.Methods: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes.Results: B-cell lymphoma (n = 504, 86.7{\%}) was more frequent than T-cell lymphoma (n = 77, 13.3{\%}). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4{\%}), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5{\%}). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28{\%} versus 71{\%}, P < 0.001). B symptoms were relatively uncommon (20.7{\%}), and bone marrow invasion was a rare event (7.4{\%}). The ileocecal region was the most commonly involved site (39.8{\%}), followed by the small (27.9{\%}) and large intestines (21.5{\%}). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77{\%} versus 57{\%}, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72{\%}) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status ≥ 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival.Conclusions: The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection.",
author = "Kim, {Seok J.} and Choi, {Chul W.} and Mun, {Yeung Chul} and Oh, {Sung Y.} and Kang, {Hye J.} and Lee, {Soon I.} and Won, {Jong H.} and Kim, {Min K.} and Kwon, {Jung H.} and Kim, {Jin S.} and Kwak, {Jae Yong} and Kwon, {Jung M.} and Hwang, {In G.} and Kim, {Hyo J.} and Lee, {Jae H.} and Sukjoong Oh and Park, {Keon W.} and Cheolwon Suh and Kim, {Won S.}",
year = "2011",
month = "7",
day = "29",
doi = "10.1186/1471-2407-11-321",
language = "English",
volume = "11",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",

}

Kim, SJ, Choi, CW, Mun, YC, Oh, SY, Kang, HJ, Lee, SI, Won, JH, Kim, MK, Kwon, JH, Kim, JS, Kwak, JY, Kwon, JM, Hwang, IG, Kim, HJ, Lee, JH, Oh, S, Park, KW, Suh, C & Kim, WS 2011, 'Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)', BMC cancer, vol. 11, 321. https://doi.org/10.1186/1471-2407-11-321

Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL). / Kim, Seok J.; Choi, Chul W.; Mun, Yeung Chul; Oh, Sung Y.; Kang, Hye J.; Lee, Soon I.; Won, Jong H.; Kim, Min K.; Kwon, Jung H.; Kim, Jin S.; Kwak, Jae Yong; Kwon, Jung M.; Hwang, In G.; Kim, Hyo J.; Lee, Jae H.; Oh, Sukjoong; Park, Keon W.; Suh, Cheolwon; Kim, Won S.

In: BMC cancer, Vol. 11, 321, 29.07.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)

AU - Kim, Seok J.

AU - Choi, Chul W.

AU - Mun, Yeung Chul

AU - Oh, Sung Y.

AU - Kang, Hye J.

AU - Lee, Soon I.

AU - Won, Jong H.

AU - Kim, Min K.

AU - Kwon, Jung H.

AU - Kim, Jin S.

AU - Kwak, Jae Yong

AU - Kwon, Jung M.

AU - Hwang, In G.

AU - Kim, Hyo J.

AU - Lee, Jae H.

AU - Oh, Sukjoong

AU - Park, Keon W.

AU - Suh, Cheolwon

AU - Kim, Won S.

PY - 2011/7/29

Y1 - 2011/7/29

N2 - Background: Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are warranted.Methods: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes.Results: B-cell lymphoma (n = 504, 86.7%) was more frequent than T-cell lymphoma (n = 77, 13.3%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4%), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5%). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28% versus 71%, P < 0.001). B symptoms were relatively uncommon (20.7%), and bone marrow invasion was a rare event (7.4%). The ileocecal region was the most commonly involved site (39.8%), followed by the small (27.9%) and large intestines (21.5%). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77% versus 57%, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72%) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status ≥ 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival.Conclusions: The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection.

AB - Background: Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are warranted.Methods: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes.Results: B-cell lymphoma (n = 504, 86.7%) was more frequent than T-cell lymphoma (n = 77, 13.3%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4%), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5%). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28% versus 71%, P < 0.001). B symptoms were relatively uncommon (20.7%), and bone marrow invasion was a rare event (7.4%). The ileocecal region was the most commonly involved site (39.8%), followed by the small (27.9%) and large intestines (21.5%). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77% versus 57%, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72%) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status ≥ 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival.Conclusions: The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection.

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