Multicomponent, tumor-homing chitosan nanoparticles for cancer imaging and therapy

Jaehong Key, Kyeongsoon Park

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues. Nanotechnologies for cancer treatment have the clear objective of solving these issues. Nanoparticles have been developed to more accurately differentiate early-stage malignant tumors and to treat only the tumors while dramatically minimizing side effects. In this review, we focus on recent chitosan-based nanoparticles developed with the goal of accurate cancer imaging and effective treatment. Regarding imaging applications, we review optical and magnetic resonance cancer imaging in particular. Regarding cancer treatments, we review various therapeutic methods that use chitosan-based nanoparticles, including chemo-, gene, photothermal, photodynamic and magnetic therapies.

Original languageEnglish
Article number594
JournalInternational journal of molecular sciences
Volume18
Issue number3
DOIs
Publication statusPublished - 2017 Mar 8

Fingerprint

homing
Chitosan
Nanoparticles
Tumors
therapy
Oncology
tumors
cancer
Imaging techniques
nanoparticles
Tissue
Neoplasms
Chemotherapy
Radiotherapy
Magnetic resonance
Nanotechnology
Therapeutics
Genes
gene therapy
optical resonance

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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abstract = "Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues. Nanotechnologies for cancer treatment have the clear objective of solving these issues. Nanoparticles have been developed to more accurately differentiate early-stage malignant tumors and to treat only the tumors while dramatically minimizing side effects. In this review, we focus on recent chitosan-based nanoparticles developed with the goal of accurate cancer imaging and effective treatment. Regarding imaging applications, we review optical and magnetic resonance cancer imaging in particular. Regarding cancer treatments, we review various therapeutic methods that use chitosan-based nanoparticles, including chemo-, gene, photothermal, photodynamic and magnetic therapies.",
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Multicomponent, tumor-homing chitosan nanoparticles for cancer imaging and therapy. / Key, Jaehong; Park, Kyeongsoon.

In: International journal of molecular sciences, Vol. 18, No. 3, 594, 08.03.2017.

Research output: Contribution to journalReview article

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